The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $444,688 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Cincinnati. The grant supports a 2-year research project to characterize cyclic AMP (cAMP) signaling microdomains in the protozoan parasite Trypanosoma cruzi, which causes Chagas disease. The research aims to elucidate the specific roles of cAMP signaling in cellular adhesion, metacyclogenesis, and osmotic...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports a $453,429 research project on the "Regulation of RNA Editing in Two Life Cycle Stages of Trypanosoma brucei". The 5-year project aims to investigate the key proteins and mechanisms involved in differential RNA editing across the life cycle of this pathogenic kinetoplastid protozoan, which alternates between mammalian...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This Project Grant award of $416,165 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate blood fitness genes in the tsetse fly symbiont Sodalis glossinidius. The central hypothesis is that S. glossinidius requires specific genes to access nutrients and survive within the blood-rich tsetse fly gut environment. The research goals are to screen S. glossinidius transposon libraries for candidate...
This Project Grant award of $438,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop new tools to facilitate drug discovery for pathogen proteasomes. The funded project at the University of California, San Diego aims to address two key bottlenecks in advancing research on parasite proteasomes - the difficulty in isolating and purifying parasite 20S proteasome enzymes,...
This Project Grant award of $699,814 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, aims to study molecular mechanisms of Plasmodium parasite invasion in Anopheles mosquito midguts to identify novel targets for transmission-blocking malaria vaccines. The key products and services to be delivered under this award include: Functional characterization of identified mosquito and parasite proteins that mediate...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $242,185 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M Agrilife Research. The grant supports research to investigate the role of RNA structure in regulating developmental RNA editing in pathogenic trypanosomes, such as Trypanosoma brucei. The key objectives are to: 1) Develop a new technique to assess RNA structure under native cellular conditions versus in vitro,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $408,865 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College. The grant supports the development of new tools to study how the protozoan parasite Toxoplasma gondii delivers its "rhoptry effector" proteins into host cells during the invasion process. The goals are to: 1) Develop an assay to test whether the rhoptry...
This Project Grant award of $1,283,899.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to investigate treatment outcomes and disease prevention strategies for Chagas disease. The primary awardee, the University of Georgia Research Foundation, Inc., will conduct studies in a natural setting of high-intensity Trypanosoma cruzi infection in working dogs in South...
This $435,875 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, Merced to interrogate the role of the transcriptional regulator NFKBID in humoral immunity against the parasite Toxoplasma gondii. The research aims to define how NFKBID-deficient T follicular helper cells impact B cell antibody responses, and examine the contribution of NFKBID-dependent...
This $736,920 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine the atomic-level structure, assembly, and function of the flagellum in the protozoan parasite Trypanosoma brucei. T. brucei causes African trypanosomiasis, also known as sleeping sickness, a fatal disease for which no vaccine exists. The research aims to leverage advanced cryo-electron microscopy and molecular genetics techniques to unveil the structure and mechanisms of the trypanosome flagellum, which is critical for the parasite's motility, signaling, and host interactions. The 5-year project at the University of California, Los Angeles is expected to produce atomic models of the flagellum that could reveal potential therapeutic targets for treating this and related neglected tropical diseases.