Project Grant K01AG092922
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $1,259,124 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025 through July 31, 2030. The award supports biomedical research investigating the role of mechanoaging—age-associated mechanical stiffening of tissues—in the deterioration of intestinal homeostasis and its contribution to inflammaging (chronic,...
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $269,452 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 18, 2026, with a completion date of November 30, 2028. The project, titled "Deciphering Proteomic Aging: From Causal Mechanisms to Frailty Prediction," delivers research services focused on identifying causal drivers of biological aging and developing...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $698,690 Project Grant to the University of Wisconsin–Madison (effective February 1, 2026, through January 31, 2031) under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of fiber type-specific skeletal muscle dysfunction with aging. The research addresses a significant health care problem: age-related loss of muscle mass and power-generating capacity (sarcopenia and dynapenia) that...
- Federal Grant Award Summary Boston University Medical Campus received a $327,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 5, 2025, with completion scheduled for August 31, 2027. The grant supports research exploring heterogeneity of cognitive trajectories in preclinical Alzheimer's disease through digital phenotyping methodologies. The project leverages multimodal data integration, combining traditional...
- Federal Grant Award Summary Brigham & Women's Hospital, Inc. received a $135,540 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 1, 2026, through June 30, 2028. This K99/R00 award funds research investigating microbial aging dynamics and their relationship to cognitive health through a multi-omics approach. The project delivers research products examining how genetic predispositions to Alzheimer's disease and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $157,760 to Massachusetts General Hospital's Research Management Division on August 20, 2026, under the Aging Research program (CFDA 93.866). The award supports a one-year research project investigating a novel mechanism of autophagic degradation in cellular senescence. The research focuses on understanding how autophagy—a cellular self-digestion process—functions specifically in senescent...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $6.42 million Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded September 15, 2025, with completion scheduled for September 14, 2029. This award supports a longitudinal research initiative examining how Mediterranean versus Western diet composition moderates cognitive aging trajectories and neuropathology in middle-aged male and female cynomolgus monkeys. The...
- Federal Grant Award Summary The National Institute on Aging awarded University of Massachusetts Medical School a Project Grant of $452,783 under the Aging Research program (CFDA 93.866) to conduct biomedical research on molecular mechanisms of neuronal cell death and neurodegeneration. The award period runs from June 1, 2026, through May 31, 2028. The project delivers research services focused on understanding how to protect the brain from Alzheimer's disease by investigating the relationship...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts a $1.35M Project Grant effective August 15, 2025, through July 31, 2030, under the Aging Research program (CFDA 93.866). This research initiative will investigate the neuromechanical bases for increased energy cost of walking in older adults, a significant contributor to age-related mobility loss and associated public health concerns. The project will deliver comprehensive scientific...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Wake Forest University Health Sciences a $3.16 million Project Grant under the Aging Research program (CFDA 93.866) effective June 1, 2026, through May 31, 2030, to conduct research examining the effects of caloric restriction on aging biomarkers, frailty, and multimorbidity in obese older adults. The research will determine whether short-term caloric restriction affects a consensus-derived blood-based biomarker index...
Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $125,848 to Tufts University School of Medicine on July 2, 2026, under the Aging Research program (CFDA 93.866) to support research through April 30, 2031. This project investigates the biological mechanisms linking dietary fiber intake to physical frailty and mild cognitive impairment in older adults through multi-omic analysis. The research integrates metabolomic and proteomic data with dietary fiber intake assessments across multiple fiber sources—total dietary fiber, fruits, vegetables, cereals, and nuts/legumes—to elucidate previously unknown biological pathways. The principal deliverables include identification of metabolomic and proteomic profiles associated with specific fiber intake sources using multivariate linear regression and machine learning models, as well as mediation analyses determining the extent to which these profiles explain the protective effects of fiber consumption on frailty and cognitive impairment. The study utilizes longitudinal data from three established cohorts: the Framingham Heart Study Offspring Cohort, the Long Life Family Study, and the Integrative Longevity Omics Study. Aim 1 evaluates how identified multi-omic profiles mediate associations between dietary fiber intake and physical frailty, while Aim 2 assesses their relationship to cognitive impairment. This research addresses a significant public health need, as the prevalence of declining physical and cognitive function is expected to increase substantially as the population of older adults nearly doubles by 2060, yet few modifiable risk factors for these conditions have been established.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.8k | 7/6/26 |