Project Grant K01AG086598

Award Date 8/15/24
Completion Date 5/31/29
Dollars Obligated $124K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Bloomington, IN 47405, USA
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The National Institute on Aging (NIA) awarded a $441,612 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Trustees of Boston University, doing business as Boston University Medical Campus. The grant, effective May 15, 2025 through January 31, 2030, will leverage the Framingham Heart Study's digital cognitive data to evaluate the relationship between the Life's Essential 8 metrics for modifiable risk factors and digital cognitive markers for early detection of...
The National Institute on Aging (NIA) awarded a $2,494,096 Project Grant (CFDA 93.866 - Aging Research) to Brigham & Women's Hospital Inc. to develop a web-based platform for early detection and sensitive tracking of cognitive changes related to Alzheimer's disease (AD). The project aims to leverage a multi-day learning curve assessment to identify diminished learning as an early indicator of preclinical AD. In Aim 1, the researchers will develop a summary score from this assessment and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $622,401.00 to the University of Southern California to conduct a multi-arm research project focused on Alzheimer's disease and related dementias (ADRD). The key objectives of the project are to: 1) Use advanced deep learning and event-based modeling to predict amyloid beta load from diffusion MRI data in both symptomatic and pre-symptomatic individuals; 2) Generate individualized whole-brain...
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This $730,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive study examining the use of digital markers from everyday life activities, such as driving behavior and physical mobility, to identify preclinical Alzheimer's disease (AD) and cognitive impairment among older adults. The key objectives are to: 1) determine the ability of digital markers of social isolation and life space to distinguish older adults with and without...
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This is a $123,530.00 Project Grant awarded by the National Institute on Aging (NIA), which administers the Aging Research program (CFDA 93.866). The award supports a research project titled "Developing a Naturalistic Paradigm for Early Detection of Cognitive Impairment" at Indiana University Bloomington.

The key objectives of the project are to: 1) identify relationships between cognitive performance, perceived stress, and psychiatric symptoms in older adults; 2) develop natural language processing algorithms to detect risk factors for depression in midlife and older adults; and 3) conduct ecological momentary assessments of daily cognitive functioning, emotions, and stress in older adults using mobile cognitive tasks. This multifaceted approach aims to establish a naturalistic framework for early detection of cognitive decline, which could enable earlier interventions to slow disease progression. The 5-year project period runs from August 15, 2024 through May 31, 2029.

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