This Project Grant award, titled "LIFE-SPACE, ISOLATION, AND FUNCTIONAL EXPOSOME STUDY IN PRECLINICAL ALZHEIMER'S DISEASE AND COGNITIVE ENVIRONMENTS (LIFESPACE)", is funded by the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $730,089. The overarching goal of this 5-year study is to examine and improve the validity and generalizability of digital signals collected from everyday life activities, such as driving and daily living, in identifying biological markers of preclinical Alzheimer's disease (AD) using a large, diverse cohort. Specific aims include: 1) determining the ability of digital markers of social isolation and life space to distinguish between cognitively normal older adults with and without preclinical AD, 2) modeling longitudinal trajectories of driving behavior and physical activity to assess life space constriction and social isolation over time, and 3) exploring the effects of social determinants of health factors, including air pollution, neighborhood characteristics, and cognitive stimulation, on social isolation and life space. The study will leverage existing institutional infrastructure to longitudinally follow 500 cognitively normal older adults across two geographically distinct sites in St. Louis, Missouri and Greenville, South Carolina.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $730.1k | 5/30/25 |