Project Grant K01AA032874
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of North Carolina at Chapel Hill $444,576 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to evaluate GLP-1 receptor agonists on alcohol-related behaviors. The recipient will conduct a preclinical screening pipeline assessing how GLP-1 receptor agonist compounds—including semaglutide, tirzepatide, and retatrutide—affect alcohol subjective and interoceptive effects and alcohol reinforcement in the...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $151,040 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate orexinergic neuronal circuits and their role in alcohol dependence and excessive ethanol consumption. The project examines functional changes in orexinergic activity in male and female mice following chronic intermittent ethanol exposure, with particular focus on the lateral hypothalamic area-ventral...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of North Carolina at Chapel Hill $653,214 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the mechanisms by which adolescent binge drinking induces lasting epigenetic suppression of basal forebrain cholinergic neurons and cognitive deficits in adulthood. The research addresses how adolescent intermittent ethanol exposure activates proinflammatory HMGB1 signaling, leading to loss of...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Boston University $580,556 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of pituitary adenylate cyclase activating polypeptide (PACAP) in heavy alcohol drinking and associated anxiety-like behavior. The recipient will conduct mechanistic research using animal models of heavy alcohol drinking combined with pharmacological, molecular, and viral approaches to test whether the...
- The National Institute on Alcohol Abuse and Alcoholism awarded Drexel University $450,372 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate ethanol-induced dysregulation of the astrocyte glucocorticoid system and its role in comorbid alcohol use disorder and depression, particularly in women. The research examines how chronic ethanol exposure perturbs the astrocyte glucocorticoid receptor system, which contributes to stress responsivity, aversion-related...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Trustees of The University of Pennsylvania $727,664 under the Alcohol Research Programs (CFDA 93.273) Project Grant on May 1, 2026. The award funds multi-omics spatial analysis of single mouse brain neurons and astrocytes in response to ethanol challenge to advance understanding of alcohol use disorder. The work examines how chronic ethanol exposure alters the open-chromatin landscape and cytoplasmic transcriptome of neurons,...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
The National Institute on Alcohol Abuse and Alcoholism awarded the University of North Carolina at Chapel Hill $168,915 on August 17, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the functional role of glutamatergic neurons in the cortical amygdala in regulating alcohol drinking and anxiety-related behaviors in mice exposed to chronic intermittent ethanol vapor, a model of alcohol dependence. The project runs through July 31, 2031, with performance at Chapel Hill, North Carolina. The research uses fiber photometry and chemogenetics to examine calcium activity changes in cortical amygdala vesicular glutamate transporter 2 neurons following chronic ethanol exposure and to evaluate the functional role of these neurons in alcohol-related behaviors. High-resolution functional magnetic resonance imaging combined with chemogenetics will identify functional networks activated by aversive stimuli and these neurons in both alcohol-naive and dependent mice. Optogenetic circuit mapping will further delineate discrete cortical amygdala circuits driving the observed behavioral effects. The central hypothesis posits that withdrawal-induced activation of these neurons in dependent mice drives heightened anxiety-like states that promote alcohol drinking through negative reinforcement, addressing a gap in understanding of the cortical amygdala as a potential therapeutic target for alcohol use disorders. This is a Project Grant, one of the assistance types NIAAA supports under its standard research grant mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $168.9k | 8/19/26 |