Project Grant R01AA032245
- The Project Grant award of $657,156.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research to examine the role of BK channels in alcohol-induced dysmyelination. The project aims to investigate the structural and functional correlates of myelin protein changes in a mouse model of alcohol use disorder, focusing on the effects of alcohol on oligodendrogenesis and pre-existing myelin. Key objectives include using...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), will provide $223,932 to conduct research on the role of parvalbumin inhibitory interneurons in the dorsomedial prefrontal cortex and their relationship to impulsivity and genetic risk for excessive drinking. The award to Trustees of Indiana University, Indianapolis will run from August 31, 2025 to May 31, 2026. The project aims to identify the neural...
- This Project Grant award of $147,486 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) will support research at the University of Pittsburgh to investigate the role of metabotropic glutamate receptor 5 (mGlu5) signaling in regulating synaptic transmission and plasticity onto prefrontal cortex parvalbumin-expressing interneurons (PFC PV-INs) following chronic ethanol drinking. The research will utilize ex vivo slice electrophysiology,...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This federal Project Grant award of $115,307 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a study on the effects of a ketogenic diet on alcohol intoxication. The key objectives are to use magnetic resonance spectroscopy to measure brain glutamate and GABA levels, and assess subjective and objective indices of alcohol intoxication in healthy individuals and non-treatment-seeking individuals with alcohol use...
- This Project Grant award in the amount of $404,508.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award aims to examine interleukin-1β (IL-1β) synaptic regulation and its role in cognitive impairment during early withdrawal and protracted abstinence from chronic alcohol exposure in male and female mice. The overarching goal is to determine the neuroimmune mechanisms by which chronic...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $105,132 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kentucky Research Foundation. The grant, titled "Uncovering the Functional and Mechanistic Dysregulation of Monocytes After Abstinence and Post-Abstinence Drinking," will leverage a rhesus macaque model to investigate the persistent functional, transcriptional, and epigenetic changes in peripheral monocytes induced by...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, is focused on investigating the mechanisms through which alcohol and chronic drinking affect the function of vasoactive intestinal peptide-expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex. The $459,343 award, effective from September 20, 2025 to July 31, 2030, aims to better define how alcohol modulates VIP-IN excitability, potentially through inhibition of KCNQ potassium channels. The research project will use CRISPR/Cas9 molecular approaches to systematically test the hypothesis that the unique expression of KCNQ subunits in VIP-INs confers high sensitivity to the effects of ethanol. The goal is to advance understanding of how alcohol and chronic drinking impact VIP-IN function, which may represent a promising cellular target for improving social and affective behaviors in alcohol use disorder.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $459.3k | 9/12/25 |