Project Grant R01AA032804
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $248,844 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 1, 2025, through August 31, 2028. Under this award, the institution will develop and validate blood-based RNA biomarkers for identifying, diagnosing, and monitoring treatment response in patients with alcohol use disorder (AUD). Building on...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $444,576 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to evaluate the efficacy of glucagon-like peptide-1 receptor agonist (GLP-1RA) compounds and related medications in reducing alcohol use disorder (AUD). The award, effective May 1, 2026, through January 31, 2031, supports a preclinical screening pipeline designed to...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $647,330 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded on September 12, 2025, with an ultimate completion date of July 31, 2030. The grant funds a longitudinal research initiative examining epigenetic profiles in the alcohol-naive primate cortex to identify biological risk factors predisposing individuals to alcohol...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) under its Alcohol Research Programs (CFDA 93.273) awarded $585,073 to the University of North Carolina at Chapel Hill, with an award date of September 20, 2025 and completion date of August 31, 2028. This Project Grant supports research to develop and validate an innovative Fetal Alcohol Spectrum Disorders (FASD) risk assessment tool that integrates maternal and paternal risk factors with novel measures of...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $459,343 Project Grant to the University of Pittsburgh under the Alcohol Research Programs (CFDA 93.273) to conduct fundamental neuroscience research examining the mechanisms through which alcohol affects prefrontal cortex circuits, with performance extending from September 20, 2025 through July 31, 2030. The research focuses on understanding how vasoactive intestinal peptide-expressing...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded The Medical University of South Carolina $459,707 on September 5, 2025, under the Alcohol Research Programs (CFDA 93.273) to support a five-year research project extending through May 31, 2030. This Project Grant funds basic neuroscience research investigating the physiological mechanisms underlying alcohol use disorder (AUD), specifically examining how chronic intermittent ethanol (CIE)...
- Summary of Federal Project Grant Award The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $733,704 to Lovelace Biomedical Research Institute on September 1, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a multimodal neuroimaging study examining the neural mechanisms underlying spatial memory deficits in children and adolescents exposed to prenatal alcohol exposure (PAE). The research employs functional magnetic resonance imaging (fMRI) and...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of Florida a $560,108 Project Grant on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a five-year investigation into the neurocognitive mechanisms of resilience to alcohol use disorder (AUD). The research will examine how attentional ability protects against AUD development in at-risk young adults with a family history of alcohol use disorder. This...
- Federal Grant Award Summary Funding Agency: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Federal Grant Program: Alcohol Research Programs (CFDA 93.273) Award Amount: $559,180 Award Date: September 1, 2025 Project Period: September 1, 2025 – June 30, 2030 Awardee: RTI International (Research Triangle Institute), Research Triangle Park, North Carolina RTI International will conduct multi-omic research to identify neurobiological factors underlying alcohol use disorder (AUD) with...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $2.55 million Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 5, 2025, with a completion date of August 31, 2029. The award supports a four-year research initiative investigating the insula-bed nucleus of the stria terminalis (BNST) neural circuit's role in alcohol use disorder (AUD) development. The...
The University of North Carolina at Chapel Hill received a $653,214 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded May 1, 2026, with completion targeted for January 31, 2031. This research project investigates the mechanisms by which adolescent binge drinking induces long-term cognitive deficits in adulthood through proinflammatory signaling and epigenetic suppression of cholinergic neurons. The research utilizes adolescent intermittent ethanol (AIE) models to examine how high-mobility group box 1 (HMGB1) protein signaling and reduced nerve growth factor (NGF) transport contribute to reversible epigenetic changes in basal forebrain cholinergic neurons, with the goal of identifying novel therapeutic targets—specifically the EHMT2 enzyme—to reverse persistent neuropathology caused by adolescent alcohol exposure. The project delivers fundamental biomedical research products including mechanistic characterization of alcohol-induced neuroinflammation and epigenetic changes, preclinical findings on potential pharmacological interventions to restore cholinergic neuron function, and evidence-based knowledge applicable to developing improved prevention and treatment strategies for alcohol use disorder and alcohol-related cognitive decline. These research outputs support NIAAA's mission to develop improved treatment methods and prevention strategies for alcoholism and alcohol-related problems through investigations of genetic and biological factors contributing to alcohol-related medical complications.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $653.2k | 5/5/26 |