Project Grant HT94252510479

This $444,125 Project Grant, awarded on July 18, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The key objectives are to: 1) Use mouse models to assess how modulating progesterone receptor signaling affects migraine...

This Project Grant award of $2,755,796.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will fund a prospective longitudinal case-control study to investigate the hormonal mechanisms linking perimenopause, inflammation, and mood symptoms. The principal investigator will recruit women seeking premenopausal risk-reducing bilateral salpingo-oophorectomy (BSO) surgery and age-matched premenopausal controls having non-BSO...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,516,765 to the University of California, Los Angeles (UCLA) to develop and validate an innovative near-infrared spectroscopy (NIRS) technology for the quantitative assessment of pelvic floor muscle function in patients with myofascial pelvic pain (MPP). The research aims to establish NIRS as an effective, non-invasive,...

This $1,361,648 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a multi-scale, multi-modal longitudinal imaging study to examine the association of cognitive function with changes in brain structure, function, and neuronal integrity in patients with multiple sclerosis (MS). The primary research objectives are to: 1)...

This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a multi-site study to examine the role of neuroactive steroids and GABA-A receptor plasticity in premenstrual dysphoric disorder (PMDD) and its treatment with low-dose selective serotonin reuptake inhibitors. The $486,416 award, effective September 11, 2024 through June 30, 2029, will assess plasma neuroactive steroid changes, GABA-A...

The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," will conduct a 5-year study to elucidate the brain and cognitive changes that occur during the perimenopause phase of the menopause transition, and the factors contributing to these changes. The study will recruit 224 women in the late...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $414,376 to the University of North Carolina at Chapel Hill to study the modulation of beta oscillatory rhythms in stroke patients to promote corticomuscular circuit function. The key objectives are to determine the modulatory effects of beta-burst repetitive...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $475,475 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to conduct research on the pathophysiology of morning migraine. The key objectives of this 2-year award are to: 1) Define the quantitative and qualitative profiles of complement and purinergic receptors and regulators...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,287 to the Icahn School of Medicine at Mount Sinai to conduct a study on cognitive impairment in multiple sclerosis (MS). The goal is to develop a psychometrically valid and biologically informed model of cognitive status in relapsing-remitting and progressive MS by...

This Project Grant award of $6,154,752, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research aimed at understanding how menstrual pain and bladder hypersensitivity interact to promote chronic pelvic pain (CPP). The 3-year study, starting on September 17, 2024, will be conducted by Endeavor Health Clinical Operations, a non-profit research institute at Evanston Hospital. The project will...