Project Grant R01MH134904

Award Date 9/11/24
Completion Date 6/30/29
Dollars Obligated $486K
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Maryland, USA
Similar Awards
The federal Project Grant award for R01MH135896, titled "IDENTIFICATION AND VALIDATION OF EPIGENETIC BIOMARKERS OF PMDD", is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The primary aim of this $641,263 grant, awarded on December 20, 2024, is to explore whether certain epigenetic biomarkers may represent a broad marker for hormone sensitivity in premenstrual dysphoric disorder (PMDD) by assessing women with...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $1,531,300.00 to the Rector & Visitors of the University of Virginia to study allopregnanolone and GABA-A receptor plasticity in premenstrual dysphoric disorder (PMDD). The 5-year study, spanning from August 1, 2024 to April 30, 2029, will examine three key aspects of GABAergic function in PMDD: 1) fluctuations in GABAergic neurosteroids like...
This $563,934 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at Tufts University School of Medicine to study the role of membrane progesterone receptors (MPRs) in mediating the effects of neuroactive steroids on neuronal excitability. The project aims to investigate how different MPR isoforms contribute to the metabotropic effects of neuroactive steroids on tonic inhibition and...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports a prospective longitudinal case-control study to investigate the hormonal mechanisms linking perimenopause to inflammation and mood symptoms. The $2,755,796 award, effective August 26, 2024 through May 31, 2029, will enable researchers at the Icahn School of Medicine at Mount Sinai to compare the time course of changes in...
This $237,000 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to investigate the role of the hormone allopregnanolone (AP) in producing long-term alterations in the medial prefrontal cortex (mPFC) function in postpartum animals. The project, titled "The Path to the Parous Brain: Allopregnanolone-Mediated Mechanisms at GABAA Receptors," will use pharmacological, chemogenetic, and CRISPR/Cas9...
This federal Project Grant award in the amount of $671,340.00 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant will fund research conducted by the University of Alabama at Birmingham (UAB) to investigate the role of the amygdala microcircuit and ovarian hormones in regulating valence processing and their potential relevance to post-traumatic stress disorder (PTSD) in women. Specifically, the research aims to...
The federal Project Grant award K23MH136325 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will provide $196,776 to the Emma Pendleton Bradley Hospital, doing business as Bradley Hospital, to conduct research on the effects of ovarian steroids on mood and sleep in adolescent females. The study will characterize hormone sensitivity in 50 female adolescents aged 11-14 years by collecting daily assessments of mood, sleep, and...
This $576,926 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a research project to characterize the cellular and molecular changes in the human anterior hippocampus across the menopausal transition. The project, led by Fordham University, will utilize single-nucleus multiome analysis and micro-C techniques to define shifts in gene expression, chromatin states, and 3D genome organization in...
This $6,154,752 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports a 3-year clinical study to understand the interplay between menstrual pain (dysmenorrhea) and the development of chronic pelvic pain (CPP) conditions. The primary objectives are to determine if optimized anti-inflammatory (NSAID) treatment for menstrual pain can reduce the future risk of CPP, and to...
This Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) federal grant program provides $2,728,777.00 in funding to the Rector & Visitors of the University of Virginia (University of Virginia) for research on neuroactive steroid biosynthesis and dynamic GABAA receptor reconfiguration in postpartum depression. The project aims to advance understanding of the biological mechanisms underlying postpartum depression, with the goal...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $485,915 to The Johns Hopkins University to study the role of neuroactive steroids and GABA-A receptor plasticity in premenstrual dysphoric disorder (PMDD). The key research activities include:

  1. Measuring fluctuations in neuroactive steroids, particularly allopregnanolone, across the luteal phase of the menstrual cycle in women with and without PMDD.
  2. Analyzing GABA-A receptor subunit expression in blood cells across the luteal phase.
  3. Examining the impact of low-dose SSRI treatment (sertraline) on these neuroactive steroid and GABA-A receptor parameters in women with PMDD.

This 5-year study aims to elucidate the pathophysiology of PMDD and clarify the mechanism of action for SSRI treatment in this condition, which may inform future targeted therapies. The award date is September 11, 2024.

Generated 7/8/25, 12:47 PM