This federal Project Grant award of $2,280,771.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop novel imaging biomarkers to diagnose and characterize myofascial trigger points in myofascial pain syndrome (MPS). The key objectives are to: (1) develop clinically-translatable PET and MRI imaging markers to reflect disease and pain mechanisms in MPS; (2) evaluate if the PET and MRI...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $6,154,752 to Endeavor Health Clinical Operations, a non-profit healthcare and research institution, over the period of September 17, 2024 to August 31, 2027. The grant will fund a randomized controlled trial (N=300) to investigate how individual variability in...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,702,003.00 to develop and assess the clinical potential of quantitative imaging biomarkers for evaluating changes in myofiber microstructure associated with masticatory myofascial pain syndrome (MMPS). The key products and services to be delivered include: 1) Establishing an optimal 15-minute MRI protocol and...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to characterize the multiscale mechanisms of pregnancy-induced remodeling of the pelvic floor muscles (PFMs). The $117,959 award, with a term from August 1, 2024 to July 31, 2026, supports experimental and computational research at the University of California, San Diego. The experimental phase will...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
This Project Grant award from the National Institute of Neurological Disorders and Stroke, under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $384,923 to Lumina Medical LLC to develop an innovative, girth-adjustable vaginal dilator with precise dilation monitoring. The goal is to significantly improve pain management for patients with pelvic floor disorders and vaginal conditions. The key products to be delivered include: A 3D printed prototype and injection-molded...
This $4.7 million project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will support the development of electrophysiological and ultrasound quantitative biomarkers for myofascial pain syndrome. The grant to Beth Israel Deaconess Medical Center will establish the use of electrical impedance myography, myofiber threshold tracking excitability testing, and ultrasound shear wave elastography to assess differences between patients with active...
This Project Grant award of $1,214,399 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of a novel minimally invasive electrode strategy to better target the posterior tibial nerve for the treatment of overactive bladder (OAB). The University of Wisconsin System, as the primary awardee, will lead the project to design, validate, and optimize an...
This federal Project Grant award of $2,935,084, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop diagnostic and prognostic ultrasound imaging biomarkers for plantar heel pain, a model of myofascial pain. The R61 phase of the project will use novel imaging techniques to create a diagnostic biosignature to objectively assess the location and severity of abnormal myofascial tissue. This will...
This federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), provides $562,735 to The Regents of the University of California, San Francisco (UCSF) to conduct a randomized controlled trial evaluating the feasibility and efficacy of a remotely delivered pelvic yoga program for women with chronic pelvic pain syndrome. The research aims to rigorously assess...