Project Grant HT94252510362

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...

The National Institute on Aging (NIA) awarded a $730,089 Project Grant under CFDA 93.866 (Aging Research) to Washington University in St. Louis. The purpose of this 5-year study, titled "LIFE-SPACE, ISOLATION, AND FUNCTIONAL EXPOSOME STUDY IN PRECLINICAL ALZHEIMER'S DISEASE AND COGNITIVE ENVIRONMENTS (LIFESPACE)", is to examine the use of digital markers from everyday activities, such as driving and physical activity, to identify biological indicators of preclinical Alzheimer's disease...

This federal Project Grant award of $187,500 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research examining the relationship between allostatic load, neighborhood disadvantage, and cognitive function trajectories among midlife and older Black Americans. The key objectives of this research project, to be conducted by Xavier University of Louisiana,...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $877,001 to The Washington University to conduct research on modeling neurofibromatosis-1 (NF1) disease heterogeneity. The goal is to mechanistically define the cellular and molecular interdependencies underlying NF1-associated low-grade gliomas and neurodevelopmental deficits, and...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $129,659 to The Johns Hopkins University to conduct a longitudinal study examining the relationship between physical activity, sleep, brain network connectivity/microstructure, and cognitive resilience in aging and preclinical Alzheimer's disease. The research aims to identify modifiable lifestyle factors and neuroimaging biomarkers that may enhance cognitive resilience and help elucidate the...

This National Institute on Aging (NIA) Project Grant award, provided under the Aging Research federal grant program (CFDA 93.866), supports a $197,569 study led by Dr. Emily Paolillo at the University of California, San Francisco (UCSF) to investigate the utility of passive smartphone monitoring to detect neurobehavioral impairment in neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The overarching goal is to evaluate whether smartphone-based digital assessment tools...

This Project Grant award of $835,056, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports the development of a multi-modal system of wearable biosensors and predictive analytics to enable continuous monitoring of mobility and cognitive function in older adults. The primary goals are to: Develop a system of flexible, breathable, and inconspicuous eutectogel sensor patches that can provide real-time monitoring of biophysical domains like gait, posture, heart rate,...

This federal Project Grant award of $826,902 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the dynamic relationships of physical activity, sleep, and circadian rhythms with heterogeneity in clinical symptoms and neurobehavioral functioning in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The award will fund a micro-longitudinal study leveraging wearable technology to objectively track daily...

The National Science Foundation awarded a $332,602 Project Grant to the University of Texas at Austin under the Social, Behavioral, and Economic Sciences federal grant program (CFDA 47.075). The award will support research from October 2021 through September 2022 to study the relationship between habitual sleep quality, neural activity in episodic memory networks, and episodic memory performance across the adult lifespan. A diverse sample of 90 young, middle-aged, and older adults without...

This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research provides $1,532,721 in funding to the University of Delaware to conduct a 3-year longitudinal study on the impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging. The study aims to determine the early mechanisms linking vascular risk factors with the loss of brain tissue structure and function, including examining the spatial and temporal relationships between...