Project Grant HT94252410871

This $233,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research at The Washington University to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and...

This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,638,424 to the University of California, San Diego from August 1, 2022 to July 31, 2025. The grant will support research developing novel quantitative magnetic resonance imaging techniques to directly image myelin and quantify myelin content and properties in the brain. Specifically, the researchers will use ultra-short echo time sequences with echo...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) provides $424,234 to The Leland Stanford Junior University to conduct research on in vivo tracking of innate immune activation and therapeutic response in mouse models of multiple sclerosis (MS) using the PET radiotracer [18F]OP-801. The research aims to leverage this novel radiotracer to obtain real-time molecular...

This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...

This Cooperative Agreement award of $3,310,951 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop and validate advanced in vivo MRI techniques, analytical tools, and plasma biomarkers to characterize the vascular pathophysiology underlying Amyloid-Related Imaging Abnormalities (ARIA) in a longitudinal cohort. The research team at New York University...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is focused on the development of novel positron emission tomography (PET) radiotracers targeting the tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) for specific imaging of microglial responses. The $618,670 award to The Washington University will support research...

This federal Project Grant award of $677,801, provided by the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports research at Yale University to develop a non-invasive magnetic resonance imaging (MRI) technique called Deuterium Metabolic Imaging (DMI) for detecting and monitoring disease progression in patients with glioblastoma, an aggressive brain tumor. The key objectives are to: 1) validate the specificity of DMI for detecting active...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $455,009 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop a novel [18F]-labeled amphiphilic PET probe that can cross the blood-brain barrier and track CD206+ microglia/macrophages in Alzheimer's disease. The goal is to create a non-invasive imaging method to detect anti-inflammatory M2-like microglia and macrophages, which play a key role in...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $476,993 to Yale University to develop new methods for measuring white matter hyperintensities (WMH) using low-field portable MRI (PMRI) technology. The project aims to create both a qualitative WMH grading scale and a quantitative machine learning-based WMH volume...

This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,969,644 to develop a novel positron emission tomography (PET) imaging probe targeting myeloperoxidase (MPO) activity for detecting neuroinflammation in neurodegenerative diseases. The Massachusetts General Hospital will design and screen potential PET agents for detecting MPO activity in the brain, characterize and validate candidate MPO PET...