Project Grant R21EB037898
- This $598,134 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of a novel imaging detector module. The project aims to create an advanced SPECT imaging system that can provide spatial and directional information without rejecting photons, enabling more precise and personalized dosimetry for therapeutic...
- This $633,218 project grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop innovative methods for introducing radiolabeled trifluoromethyl groups into molecules for use as positron emission tomography (PET) tracers. The key objectives are to: Develop a general strategy to transform alkyl halides into their corresponding...
- This $384,863 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program supports research to develop a novel radiotracer imaging agent for detecting Gram-positive bacterial infections associated with implanted medical devices. The key products and services to be delivered include: In vitro testing of a bivalent radiotracer agent...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,969,644 to develop a novel positron emission tomography (PET) imaging probe targeting myeloperoxidase (MPO) activity for detecting neuroinflammation in neurodegenerative diseases. The Massachusetts General Hospital will design and screen potential PET agents for detecting MPO activity in the brain, characterize and validate candidate MPO PET...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $426,250 to Wake Forest University Health Sciences to develop and evaluate a novel positron emission tomography (PET) radiotracer, [11C]TM-N1324, to measure levels of the G-protein coupled receptor GPR39 in rodent models and postmortem human brain tissues of Alzheimer's disease (AD). The project aims to establish the utility of this PET imaging approach for quantifying GPR39, which is implicated...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of radiofluorination methods and prosthetic groups for rapid construction of PET tracer analogs. The $122,260 award to the University of North Carolina at Chapel Hill will fund research to promote the utilization of quick candidate screening strategies...
- This Project Grant award of $431,750 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports the development of an innovative PET molecular neuroimaging technique to non-invasively image whole-brain neurocircuitry in awake mammals. The technique utilizes a brain-penetrant PET imaging probe and a neuronal activity-dependent...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $455,009 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop a novel [18F]-labeled amphiphilic PET probe that can cross the blood-brain barrier and track CD206+ microglia/macrophages in Alzheimer's disease. The goal is to create a non-invasive imaging method to detect anti-inflammatory M2-like microglia and macrophages, which play a key role in...
- This federal Project Grant award, valued at $782,495.00 and provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to develop a novel positron emission tomography (PET) ligand that can selectively image the enzyme poly(ADP-ribose) polymerase-1 (PARP1) in the living human brain. PARP1 dysregulation has been implicated in Alzheimer's disease and other neurodegenerative disorders, but there are currently no successful examples of imaging PARP1 in the human brain. The...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the federal Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $174,375.00 to The Johns Hopkins University from December 5, 2024 to November 30, 2027. The project aims to develop new methods for incorporating the radioactive isotope fluorine-18 into complex biomolecules using metal-fluorine bond formation. This will...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is focused on the development of novel positron emission tomography (PET) radiotracers targeting the tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) for specific imaging of microglial responses. The $618,670 award to The Washington University will support research to 3H-radiolabel lead THIK-1-targeted small molecule compounds, assess their specificity and concordance with neuroinflammatory markers in vitro, and subsequently develop 18F-radiolabeled ligands to evaluate their in vivo biodistribution and brain penetrance in healthy mouse models. The ability of these THIK-1 radiotracers to detect changes in microglial responses will also be assessed in animal models of Alzheimer's disease and multiple sclerosis. This innovative project aims to develop the first THIK-1-PET approach for highly specific and functionally relevant imaging of microglia, which plays a critical role in neurodegenerative diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/27/25 | ||
| Not listed | $618.7k | 7/30/25 |