Project Grant HT94252410177

The University of Pittsburgh - Of The Commonwealth System of Higher Education received a $571,404 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on examining the long-term therapeutic potential of an adiponectin receptor agonist in promoting functional recovery after traumatic brain injury (TBI)....

The University of Pittsburgh is receiving a $437,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant aims to provide proof-of-concept evidence that retinoic acid (RA) can attenuate cholinergic deficits and white matter connectivity impairments after traumatic brain injury (TBI). The two-year project will: 1) determine if RA treatment...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $587,521.00 to the Regents of the University of Michigan to conduct research on mitochondrial modulation therapy for traumatic brain injury (TBI). The key objectives of this 5-year research project are to: (1) explore the molecular mechanisms of neurotrauma and the...

This Project Grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will support the development of novel gyrencephalic animal models to study the neuropathological and clinical features of post-traumatic brain injury (TBI) neurodegeneration. The award, totaling $3,102,638, will fund research to create preclinical TBI models that recapitulate the complex pathologies and phenotypes observed in the chronic phase following injury. Key activities...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $449,460 supports research to investigate the role of aberrant PTEN signaling in microglia as a driver of tau pathology, neurodegeneration, and cognitive decline following repetitive mild traumatic brain injury (r-mTBI). The Roskamp Institute, a non-profit biotechnology research organization, will use this funding to expand on their previous work by developing a tamoxifen-inducible model...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...

The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $379,171 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports a 2-year research project to investigate cerebrovascular dysfunction and cerebral atrophy in severe traumatic brain injury (STBI). Specifically, the project aims to: 1) Characterize...

This $274,855 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a novel fusion protein construct (NFP) that can cross the blood-brain barrier and deliver a therapeutic payload to repair mitochondrial DNA damage in neurons following traumatic brain injury (TBI). The key objectives of this 8-month research and development effort are to: 1) verify the NFP's technical capability to...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $739,772 Project Grant (CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders) to Cian, Inc. for the development of a cilia biomarker kit to improve diagnosis and prognosis of traumatic brain injury (TBI). The key products and services to be delivered under this grant include: 1) developing specific monoclonal antibodies targeting proteins expressed in cilia, which are disrupted in...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $195,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the University of Texas Health Science Center at Houston (UTHealth). The grant, titled "Sharp Wave Ripple Stimulation as a Potential Strategy to Enhance Memory After TBI", aims to investigate whether optogenetic or pharmacological stimulation of hippocampal...