Project Grant R21NS130468
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
- This Project Grant award of $559,820 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by the University of South Carolina to characterize the biomechanical response of the human brain during traumatic brain injury (TBI). The research aims to integrate dynamic MRI and sonomicrometry techniques to measure brain deformation at both low and high...
- The University of South Florida (USF) was awarded a $749,987 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding, with an award date of August 15, 2023, supports research to characterize the role of a novel mechanistic pathway involving fibrinogen, sphingolipids, and caveolar transcytosis during traumatic brain injury (TBI) as an example...
- The University of Illinois, doing business as The Board of Trustees of the University of Illinois, received a $457,049 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders. The grant, awarded on Sep 15, 2023, will fund research to apply human in vitro models to understand the link between traumatic brain injury (TBI) and tau pathology in Alzheimer's disease and...
- This $453,970 Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will support research by the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to investigate the effects of intranasal HB-EGF treatment on brain glucose metabolism and inflammation following pediatric traumatic brain injury (TBI). The 2-year project aims to determine if HB-EGF...
- This $453,860 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The grant, awarded to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences, aims to...
- This $177,188 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at The Ohio State University to explore the role of NF-kB in chronic inflammation, microglia priming, and neuropsychiatric complications following traumatic brain injury (TBI). The key objectives are to determine the therapeutic potential of an NF-kB inhibitor...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $465,752 to the Regents of the University of Michigan - Dearborn to conduct research on understanding changes in cell chirality and cell-cell interactions within the neurovascular unit (NVU) after traumatic brain injury (TBI). The project aims to evaluate TBI-induced...
- This federal Project Grant award of $532,385 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and evaluation of a novel targeted nanotherapeutic delivery platform for treating brain disorders. The primary product being developed is a 2-deoxy-D-glucose (2DG)-based glycodendrimer nanoplatform (2DG-D) designed to selectively deliver...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $379,171 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports a 2-year research project to investigate cerebrovascular dysfunction and cerebral atrophy in severe traumatic brain injury (STBI). Specifically, the project aims to: 1) Characterize cerebrovascular permeability and immune cell composition in STBI, and 2) Determine the effectiveness of engineered chondroitin sulfate 3D matrix implants in mediating cerebrovascular repair and functional recovery in a preclinical rat model of penetrating STBI. The proposed research is expected to provide novel insights into the role of cerebrovascular dysfunction in progressive neurodegeneration and cerebral atrophy following STBI, and inform the development of tissue engineered brain implants to accelerate cerebrovascular repair and prevent brain volume loss and functional deficits in STBI patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $379.2k | 9/18/23 |