Project Grant HT94252310645

This federal Project Grant award of $188,307 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop a guided, web-based intervention combining Acceptance and Commitment Therapy (ACT) for chronic pain and Mindfulness-Based Relapse Prevention (MBRP) for substance use disorders. The project, led by Principal Investigator Dr. Edwards, will involve collaborating with 12-15 patients with lived experience of chronic pain and...

This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support research to determine the role of endogenous opioids in the dorsal raphe nucleus (DRN) in regulating motivational and affective behaviors during chronic pain. The $233,088 award to The Washington University will fund experiments using dual-color one-photon endoscopic imaging to examine how DRN enkephalin neurons contribute to the...

The U.S. National Institute on Drug Abuse (NIDA) awarded a $529,990 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The purpose of the grant is to optimize and examine the feasibility and acceptability of an adaptive psychological intervention to improve pain and reduce opioid use in patients hospitalized after a musculoskeletal injury. The proposed...

This federal Project Grant award, valued at $1,485,691 and awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to evaluate the neural correlates and behavioral impact of withdrawal-induced hyperalgesia among people who smoke with and without chronic pain. The key objectives of this research project are to: 1) Assess the impact of smoking withdrawal on brain fMRI-based response to noxious heat stimuli among...

This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $650,250 to the University of California Irvine (UCI) from Sep 1, 2025 to May 31, 2030 to study the neural mechanisms underlying motivational and cognitive impairment during opioid withdrawal. The project will investigate how dopamine and acetylcholine signaling in the nucleus accumbens and dorsomedial striatum contribute to...

The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,643,228 Cooperative Agreement grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Worcester Polytechnic Institute (WPI) to develop an Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment (IMPACT). The key objectives of this 2-year IMPACT project are to: 1) Initiate a clinical trial of Mindfulness-Based Stress Reduction (MBSR) for chronic low back pain...

This federal Project Grant award in the amount of $137,619, granted by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research at the University of Washington (UW) to investigate the role of tetrahydrocannabinol (THC) in mediating pain signaling in the basolateral amygdala (BLA). The central hypothesis is that THC acts as a partial agonist at the cannabinoid 1 receptor (CB1R) to decrease excitatory BLA neuronal...

The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded The Children's Hospital of Philadelphia (CHOP) a 5-year, $352,540 project grant titled "The Adolescent Surgery Experience: Preoperative Anticipatory Guidance and Postoperative Opioid Misuse (POM)." The grant aims to improve knowledge of effective anticipatory guidance techniques and design an intervention to prevent postoperative opioid misuse among the over 1.4...

This Cooperative Agreement was awarded by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279). The $823,860 award will fund a 4-year pragmatic randomized controlled trial to evaluate the effectiveness of Emotional Awareness and Expression Therapy (EAET) for treating chronic pain in veterans. EAET is an evidence-based psychological treatment that targets comorbid trauma and...

This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will fund the development and pilot testing of a telehealth-adapted motivational smoking cessation intervention targeted for smokers with chronic pain. The $431,643 award, running from August 1, 2025 to July 31, 2027, supports two key objectives: (1) developing telehealth protocols for the pain-targeted intervention and an active control...