This $779,969 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to improve perioperative care for patients with opioid use disorder. The grant will fund a 5-year study to prospectively capture patient-reported pain and opioid use among individuals with opioid use disorder undergoing common surgical procedures, and develop a clinical care pathway to optimize perioperative outcomes across a network of...
This federal Project Grant award from the National Institutes of Health (CFDA 93.279 - Drug Abuse and Addiction Research Programs) provides $1,105,489 to The Leland Stanford Junior University (Stanford University) to fund research aimed at reducing the risk of persistent postoperative opioid use and opioid use disorder among older adults undergoing inpatient surgery. The key products and services to be delivered under this 2-year grant include: Augmenting an existing dataset that links...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,809,660 Cooperative Agreement under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Pittsburgh to implement and personalize opioid-sparing pain management protocols for major inpatient surgeries in children. The project will investigate the efficacy and safety of a standardized methadone-based Enhanced Recovery After Surgery (ERAS) protocol, and develop personalized ERAS protocols...
This Project Grant award of $796,934 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund a single-center, randomized, double-blind, parallel-group, dose-finding trial to determine the optimal age-specific, weight-based dose of intraoperative intravenous (IV) methadone for pediatric tonsillectomy patients. The goal is to improve analgesic outcomes and...
This Project Grant award of $994,004, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to engage adolescents, young adults, parents, providers, pharmacists, and people who use drugs to generate knowledge to guide future overdose prevention interventions tailored for youth. The key objectives are to: 1) explore perceptions of overdose risk, drug supply, and safety precautions among 13-17 and 18-25 year olds through focus...
This federal Project Grant award, ID K08DA060977, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $192,780 grant will fund a 5-year research project at Stanford University to evaluate the impact of discontinuing medications for opioid use disorder (MOUD) after surgery. The central hypothesis is that postoperative MOUD discontinuation is a risk factor for adverse outcomes, and the research aims to 1) identify risk...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a research project entitled "Optimizing Developmental Outcomes in Early Childhood After Neonatal Opioid Withdrawal Syndrome." The $180,059 award, effective August 1, 2024, will fund a 5-year longitudinal study to assess the independent and moderating effects of positive childhood experiences (PCEs) and adverse childhood experiences...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a 5-year, $2,726,432 research study on co-use of cannabis and prescription opioids among emerging adults in medical settings. The study will enroll emerging adults aged 18-25 who either have no history of cannabis use or have used cannabis in the past month and are prescribed an opioid for acute pain management. Participants will be followed...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $431,750 to Rutgers, The State University of New Jersey to conduct research on informing national overdose prevention and treatment strategies for high-risk adolescents. The key objectives of this 2-year project are to: 1) estimate the prevalence of adolescent nonfatal drug overdose and identify high-risk demographic and clinical subgroups,...
The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $267,000 Project Grant (R21DA058120) to The Children's Hospital Corporation (Boston Children's Hospital) to develop depot formulations for on-demand, tamper- and diversion-proof delivery of opioids. The goal is to create injectable polymer-based depot formulations that are covalently bonded to opioids via photolabile linkers, which would make the formulations resistant to...