Project Grant FA95501410089

This three-year, $376,264 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new genetically engineered biological circuits and sensors. The University of Colorado Boulder team, led by The Regents of the University of Colorado, aims to harness plant hormone receptors to rapidly design genetic circuits controlled by user-specified ligands. They will engineer novel plant-derived chemical sensors that can recognize...

This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), will support research at Colorado State University to elucidate the design principles for synthetic signaling systems that enable precision control of gene expression. The $385,000 award, spanning August 1, 2024 to May 31, 2029, will fund research across three methods of modulating gene expression: 1) Cas9-based synthetic...

This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $305,345 to The Regents of the University of Colorado (CU) to develop tunable, nontoxic biochemical oscillators and study their behavior in cell-like systems. The key products and services to be delivered include: Reagents for building and monitoring batch biochemical oscillators A kinetic framework for modeling and adjusting oscillatory dynamics Microfluidic methods for preparing and...

The Cold Spring Harbor Laboratory will provide a two-week intensive Synthetic Biology Summer Course from August 2022 through July 2025 under a $515,458 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The course aims to introduce scientists to synthetic biology through a combination of practical lectures, open-ended research projects, and seminars led by field experts. Participants will gain hands-on experience with techniques such as cell-free...

The federal Project Grant award R01EB036085 for $1,466,982.00, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports research and development of advanced genetic circuits and diagnostic devices for ovarian cancer detection. The project aims to develop recombinase-based digital enhancer circuits and self-assembled split recombinases to...

This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $300,000 to the University of Texas at Austin to research the use of non-canonical genetic alphabets and codes to expand genetic capabilities in synthetic cells. The 3-year project (9/1/2024 - 8/31/2027) aims to: Investigate incorporating non-canonical nucleotides into genetic translation, Incorporate non-canonical amino acids via non-canonical genetic alphabets, and Use...

This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...

This $210,720 Project Grant awarded by the National Science Foundation (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences (CFDA 47.049) program supports collaborative research to develop a rigorous, mathematical theory of modularity in biological systems. The research aims to define modular structures in biological networks, determine the advantages of modularity, and leverage this understanding to reveal novel biological insights. Key objectives include: 1)...

This federal Project Grant award, with ID R01EB035127, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The total funding amount is $1,230,250.00 over the award period from June 1, 2024 to February 29, 2028. The key goal of this project is to develop an integrated experimental and computational toolkit for real-time analysis of...