The National Science Foundation (NSF) awarded a $568,480 Project Grant under the Engineering (CFDA 47.041) program to The Regents of the University of Colorado, doing business as the University of Colorado, to conduct research on a novel biosensing concept for high-sensitivity measurement of cell mechanical biomarkers. The 3-year award, effective May 1, 2024, will investigate how biological cells with different mechanical properties interact with acoustic waves propagating along a substrate, and...
This three-year, $376,264 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new genetically engineered biological circuits and sensors. The University of Colorado Boulder team, led by The Regents of the University of Colorado, aims to harness plant hormone receptors to rapidly design genetic circuits controlled by user-specified ligands. They will engineer novel plant-derived chemical sensors that can recognize...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...
This National Science Foundation Project Grant of $395,312 will fund the development of shape-encoded electrokinetic particles for multiplexed biosensing through June 2027. Under the NSF Engineering Directorate's CFDA 47.041 program, the University of Colorado Boulder will work to advance biosensing technologies that can detect heterogeneous biomarkers from blood in a single assay. Specifically, the university will study how biomarker size, charge density, and concentration influence the induced...
This $397,494 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research to study the fundamental relationships that control the assembly of solid materials from shape-changing ribbon-like particles. The research, led by The Regents of the University of Colorado, will use liquid crystal elastomers that can reversibly change shape to create porous solid materials with controlled mechanical properties and self-healing capabilities. The project...
The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the University of Utah from August 1, 2023 to July 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports the development of a novel optical biosensor capable of detecting and quantifying a wide range of biological molecules, including biomarkers found in bodily fluids. The project leverages second harmonic generation (SHG) and optical heterodyning techniques...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) provides $575,765 to Northeastern University to conduct research on enhancing the production of biochemicals from sustainable single-carbon (C1) feedstocks using anaerobic bacteria called acetogens. The key objectives are to (1) understand the regulation of carbon metabolism in acetogens, and (2) leverage this understanding to make acetogens more effective at producing valuable fuels and...
This $519,071 project grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) to Trustees of Boston University will explore the use of light-controlled metabolic engineering strategies to optimize the production of valuable chemical products like octanoic acid in microorganisms. The key objectives are to: 1) develop novel light-inducible proteins that can dynamically regulate metabolic pathways, 2) comprehensively test light induction strategies to understand their...
The Regents of the University of Colorado received a three-year, $1,149,515 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences to support research titled "Nanomechanics of Tubulin Extraction from Microtubules and Adhesin Catch-Bond Rupture." The grant is part of NSF's Biological Sciences program (CFDA 47.074), which aims to advance fundamental knowledge in biology and strengthen the Nation's scientific enterprise. Under this award,...