Project Grant 2218330
- This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $885,642 to Trustees of Boston University to conduct research aimed at defining the underlying principles behind the function of gene regulatory networks. The project uses an optogenetic strategy to test how dynamic input signals are propagated within regulatory networks with increasing levels of complexity, first in well-defined synthetic networks and then in the endogenous...
- Colorado State University will provide research, education, and outreach services under a $622,699 Project Grant from the National Science Foundation Division of Integrative Organismal Systems. The grant falls under the NSF Biological Sciences program (CFDA 47.074) and aims to facilitate the prediction and validation of plant enzyme functions through three key activities. First, CSU will deposit published plant enzyme activities into public databases to support computational function...
- This Project Grant award of $1,100,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will support research at the University of California, Davis to study the genetic and chemical processes behind the diversity of specialized metabolites in plants. The project will investigate the key biosynthetic genes and modifications that create a range of glucosinolate compounds in the Brassicales plant family, which contribute to the flavors, aromas, and health benefits...
- The Regents of the University of Colorado, doing business as the University of Colorado Denver, was awarded $333,918 under the National Science Foundation's Biological Sciences program (CFDA 47.074) to conduct collaborative research from July 1, 2023 to June 30, 2027. The university will use topological data analysis techniques to extract information embedded in plant leaf morphology and gene expression profiles, with the goal of predicting leaf shape from molecular data using deep learning...
- This $300,000 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a sustainable, intelligent wearable sensor system for continuous tree health monitoring. The primary goals are to: Create a biocompatible, ion-sensitive sensor array that can be implanted in a plant's xylem to continuously monitor water and nutrient uptake in real-time. Develop energy-harvesting techniques...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $701,884 to The Regents of the University of Colorado to develop a functional genomics tool kit for the filamentous cyanobacterium Nostoc punctiforme. The key products and services to be delivered include construction of a random barcode transposon-site sequencing library, generation of CRISPR tools for gene deletion and cargo DNA integration, and implementation of proximity...
- This National Science Foundation project grant of $300,000 supports research aimed at accelerating synthetic biology discovery through integrated curation. Funded under the Biological Sciences program (CFDA 47.074), the University of Colorado Boulder will develop an integrated curation framework and search framework to enable genetic design information sharing according to FAIR data principles. The frameworks will facilitate digital publication submissions with curated genetic sequence and...
- This National Science Foundation Project Grant of $395,312 will fund the development of shape-encoded electrokinetic particles for multiplexed biosensing through June 2027. Under the NSF Engineering Directorate's CFDA 47.041 program, the University of Colorado Boulder will work to advance biosensing technologies that can detect heterogeneous biomarkers from blood in a single assay. Specifically, the university will study how biomarker size, charge density, and concentration influence the induced...
This three-year, $376,264 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new genetically engineered biological circuits and sensors. The University of Colorado Boulder team, led by The Regents of the University of Colorado, aims to harness plant hormone receptors to rapidly design genetic circuits controlled by user-specified ligands. They will engineer novel plant-derived chemical sensors that can recognize pharmaceuticals and dietary molecules. These new sensors will then be used to construct "sentinel cells" that indicate the presence of different molecules via color changes. The team will reprogram plant sensors to recognize new molecules and link them to bacterial enzymes regulating gene expression. This will enable bacteria to change color in response to chemical inputs. The research findings will be integrated into an undergraduate discovery lab course. The project establishes a platform to rapidly construct programmable, chemically inducible RNA polymerases, allowing the design of complex genetic circuits controlled by optimized ligands for various applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $376.3k | 7/12/22 |