Project Grant F31DE035006
- Federal Grant Award Summary Baylor College of Medicine received a $453,797 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 5, 2026, with a completion date of June 4, 2028. The research project investigates the structures and functions of natural products in periodontal disease, specifically examining novel biosynthetic gene clusters found in clinical isolates of...
- Federal Project Grant Award Summary Loma Linda University received a $358,823 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective September 11, 2025, through September 10, 2027. The award funds structural-functional research on gingipain biogenesis and localization in Porphyromonas gingivalis, a keystone pathogen in periodontitis. The research addresses a critical gap in...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $568,759 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) effective May 1, 2026, through April 30, 2031, to conduct basic research on pathogen synergy and immune subversion in periodontal disease. The research deliverables include scientific investigations of how two gram-negative anaerobic...
- This Project Grant award of $770,578, obligated on August 22, 2025, supports basic and translational research on senescent periodontal ligament cells as a therapeutic target for age-associated periodontitis through the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The research, conducted by Augusta University Research Institute, Inc. in Augusta, Georgia through May 31, 2030, investigates the mechanisms by...
- Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of Massachusetts Lowell $100,676 under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a three-dimensional (3D) in vitro human periodontal sulcus tissue model for studying early biomarkers of oral dysbiosis. The award, obligated on September 30, 2026, with an ultimate completion date of April 14, 2027, funds research to create an advanced tissue culture system...
- This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pittsburgh a $454,002 Project Grant on September 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a two-year research initiative examining the dichotomy of phosphate actions in periodontal health. The research will investigate the interplay between dietary phosphate availability, its pro-osteogenic and pro-inflammatory effects, and...
- Federal Project Grant Award Summary Virginia Commonwealth University received a $310,500 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 15, 2026, with completion scheduled for June 14, 2027. The grant funds mechanistic research investigating the role of nuclear bone morphogenetic protein 2 (NBMP2) in macrophage-mediated periodontal regeneration and bone repair. The project...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $540,629 to the University of Massachusetts Lowell on August 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating human oral host-pathogen interactions and dysbiosis modulation. The project, scheduled for completion by August 14, 2027, focuses on developing and validating an immunocompetent three-dimensional (3D) in vitro model...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $423,500.00 to Nova Southeastern University, Inc. to develop a humanized mouse model of periodontitis. The goal is to investigate the potential pathogenic role of the protein Semaphorin 4D expressed by human osteoclasts in the progression of periodontal disease. This advanced mouse model will allow researchers to...
This $101,828 Project Grant, awarded December 1, 2026, by the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research conducted by Virginia Commonwealth University to characterize phospholipase A2 (PLA2) enzyme function and structure in Porphyromonas gingivalis, a keystone pathogen in periodontal disease. The research addresses a gap in understanding the pathogenic mechanisms linking elevated PLA activity in patients' gingival crevicular fluid to periodontitis development and progression. The project delivers two primary research products through its May 9, 2028 completion date: (1) biochemical and structural characterization of the PG1879 protein as a functional PLA2 enzyme, including identification of its unique biochemical properties; and (2) determination of PG1879's specific role in the pathophysiology of P. gingivalis infection. These deliverables will clarify whether elevated PLA activity in periodontal disease is attributable to pathogen-derived enzymes, host immune responses, or both factors, ultimately contributing to improved understanding of periodontal disease mechanisms and potential therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/5/26 | ||
| Not listed | $50.9k | 5/5/26 | ||
| Not listed | $50.9k | 5/5/26 |