This federal Project Grant award of $107,948 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the effects of concurrent chronic stress and cocaine self-administration on medial prefrontal cortex (mPFC) microglia and drug choice behavior. The research will be conducted by The Medical College of Wisconsin, Inc. from December 2024 through April 2028. The goal is to develop a better understanding of the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $121,323 to the University of North Carolina at Chapel Hill to investigate the structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administration in male and female rats. The research aims to: 1) explore morphological responses of accumbens microglia and evidence of astrocyte membrane...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 "Drug Use and Addiction Research Programs," provides $711,875 to the University of Massachusetts Medical School (UMass Medical) to explore the role of the neuropeptide nociceptin in suppressing cocaine reward. The 2-year project from June 2024 to May 2026 will leverage cutting-edge viral and genetic tools to characterize nociceptin signaling in the nucleus accumbens and its...
This $1,127,388 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to determine the role of the small molecule Rac1 in neuronal ensembles governing cocaine-seeking behavior. The University of Florida is the primary awardee, with the overall objective to examine how Rac1 signaling impacts the behavioral, structural, and activity characteristics of neurons associated with cocaine-seeking. The...
This National Institute on Drug Abuse (NIDA) Project Grant award under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the comorbidity of HIV and cocaine use disorders (CUDs). The $157,568 award, effective from November 13, 2024 to June 30, 2026, will be used by Drexel University to conduct a series of studies in male and female mice. The researchers will employ circuit-specific optogenetics to stimulate...
The National Institute on Drug Abuse (NIDA), an agency within the U.S. Department of Health and Human Services, awarded a $1,447,919 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Pennsylvania State University to conduct research on cocaine addiction and the "need-state hypothesis." The key objectives are to: Test whether treatment with a GLP-1 receptor agonist can block the aversive behavioral and physiological responses to a cocaine-predictive cue...
This $180,606 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research by the Icahn School of Medicine at Mount Sinai to investigate cocaine-induced changes in the synaptic proteome of medium spiny neurons in the nucleus accumbens, a key brain region involved in substance use disorders. The award will enable the principal investigator to elucidate the specific proteomic adaptations at the...
This $454,500 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant funds a research project titled "HIV Effects on Astrocytic Regulation of Stress-Induced Cocaine Reinstatement" at Drexel University. The overarching goal is to investigate the interaction between HIV infection, cocaine use, and stress responses, with a focus on understanding how astrocyte cells mediate these...
This Project Grant award of $592,998.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to develop and validate a computational neurobiological model of costly drug-taking behavior. The research aims to determine the role of the prelimbic-striosomal and striosomal-substantia nigra circuits in mediating the impact of craving on drug-cost tradeoffs and predicting vulnerable drug-taking phenotypes. The project...
This federal Project Grant award of $180,646 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the molecular mechanisms underlying the regulation of cocaine drug-seeking behavior by astrocytic CREB. The principal investigator will build an independent research program to elucidate the transcriptional and epigenetic regulation of astrocytes in the context of drug abuse and addiction. Key...