Project Grant F31CA310286
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $354,658 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025 through July 31, 2030. This award supports fundamental research investigating subclonal P27 (CDKN1B) loss as a driver of aggressive prostate cancer, with particular focus on understanding health disparities affecting Black or African American males who experience prostate cancer mortality...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $477,674 Project Grant to The Johns Hopkins University, effective June 1, 2026 through May 31, 2031, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This research initiative focuses on molecular imaging of the immune-suppressive tumor microenvironment (TME) in prostate cancer and its response to immune checkpoint inhibitor (CIT) therapy. The project will employ molecular and functional imaging...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $658,423 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031, to conduct fundamental research on therapeutic targeting of PI3K gamma-positive tumor-associated macrophages (TAMs) in metastatic castration-resistant prostate cancer (MCRPC). The research aims to develop innovative therapeutics that reduce health disparities...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a project grant of $109,076 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with a completion date of July 31, 2028. This award funds research investigating the role of acetyl-coenzyme A synthetase 2 (ACSS2) in T cell adaptation to metabolic stress within tumor microenvironments. The research addresses a critical gap in understanding how T cells survive and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $148,626 through the Cancer Research Manpower program (CFDA 93.398) to the University of Pennsylvania, effective December 1, 2025 through April 30, 2028. This Project Grant supports research training and workforce development focused on elucidating the role of N6-methyladenosine (m6A) modifications on messenger RNA (mRNA) during adaptive stress responses in prostate cancer. The research addresses a critical gap in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center $169,776 under the Cancer Research Manpower program (CFDA 93.398) for a two-year project (August 1, 2025–July 31, 2027) titled "Unraveling Myeloid-Mediated Mechanisms of Immunotherapy Resistance in Prostate Cancer Bone Metastases at Single-Cell Resolution." This project grant funds biomedical research training and investigator-initiated research focused on identifying and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute awarded a $100,228 Project Grant to The Johns Hopkins University under the Cancer Research Manpower program (CFDA 93.398) beginning December 1, 2026 and concluding November 30, 2029. This award supports research focused on engineering and optimizing mRNA-lipid nanoparticle (mRNA-LNP) vaccine compositions to enhance tissue-specific antitumor immunity. The research aims to develop cancer vaccines that can direct immune responses and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded The Johns Hopkins University a $1,020,120 Project Grant effective August 1, 2025, through May 31, 2030, to develop and clinically evaluate PROBOT, a novel ultrasound probe and robotic system designed to improve image-guided interventions for prostate cancer diagnosis and treatment. The project delivers a Phase 1 clinical trial evaluating the...
The National Cancer Institute (NCI) awarded The Johns Hopkins University a $100,228 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2026, through May 31, 2029. This award supports research training and workforce development in cancer biology aligned with the National Cancer Program's priorities. The funded project investigates the molecular mechanisms of MYC-driven transcriptional reprogramming in prostate cancer tumor microenvironments (TME). The research addresses the paradox that while benign prostate lesions exhibit immune activation, invasive prostate cancer presents an immunologically "cold" TME resistant to immunotherapy. Through Aim 1, researchers will employ single-nucleus ATAC-seq and RNA-seq analyses on human prostatectomy samples to profile transcriptomic and chromatin landscapes, identifying transcription factors and regulatory networks that drive immunogenic versus immunosuppressive programs in the transition from benign proliferative inflammatory atrophy lesions to invasive carcinoma. The project hypothesizes that SMARCD2, a critical BAF chromatin remodeling complex subunit, mediates MYC-driven reprogramming by orchestrating differential binding of key transcription factors. The ultimate objective is to translate findings into novel therapeutic strategies that reverse immunosuppression and expand treatment options for advanced prostate cancer patients.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 4/13/26 | ||
| Not listed | $0 | 4/13/26 | ||
| Not listed | $50.1k | 4/13/26 |