Project Grant R01CA287368
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $512,728 Project Grant effective August 1, 2025, through May 31, 2030, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). The award supports development and clinical evaluation of PROBOT, a novel ultrasound probe and robotic system designed to improve image-guided interventions for prostate cancer diagnosis and treatment. The project encompasses a Phase 1...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a Project Grant totaling $100,228 under the Cancer Research Manpower program (CFDA 93.398) for the project "Investigating the Molecular Mechanisms of MYC-Driven Transcriptional Reprogramming of the Tumor Microenvironment in Prostate Cancer," effective December 1, 2026, through May 31, 2029. This award supports biomedical research training and investigator-initiated research designed to...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $162,080 under the Cancer Research Manpower program (CFDA 93.398) on December 27, 2025, with a completion date of June 30, 2028. Dr. Komatsu's laboratory is conducting research to visualize and characterize B cell infiltration and aggregation within the tumor microenvironment, with particular focus on the role of high endothelial venules (HEVs) as critical gateways for...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $354,658 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025 through July 31, 2030. This award supports fundamental research investigating subclonal P27 (CDKN1B) loss as a driver of aggressive prostate cancer, with particular focus on understanding health disparities affecting Black or African American males who experience prostate cancer mortality...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $249,000 Project Grant to The Johns Hopkins University under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for a three-year project period from January 1, 2026 through December 31, 2028. The project, titled "Large-Scale Artificial Intelligence Using Radiomics, Deep Learning, and Physics-Based Generative Modeling to Improve Clinical Outcomes in Nuclear Medicine," addresses critical challenges...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Grant Award Summary The National Cancer Institute awarded Johns Hopkins University a $591,419 project grant under the Cancer Treatment Research program (CFDA 93.395) effective May 1, 2026 through April 30, 2031. The award supports the development of low molecular weight theranostics targeting multiple myeloma, a disease characterized by malignant plasma cell expansion in the bone marrow. The research addresses critical gaps in treating therapy-resistant myeloma by developing a...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $207,802 Project Grant to the University of North Carolina at Chapel Hill (effective May 1, 2026 through April 30, 2029) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop advanced imaging technologies for cellular immunotherapy research. The project will deliver two primary products: (1) novel fluorescent probes enabling simultaneous visualization of multiple proteins within immune cells,...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center $169,776 under the Cancer Research Manpower program (CFDA 93.398) for a two-year project (August 1, 2025–July 31, 2027) titled "Unraveling Myeloid-Mediated Mechanisms of Immunotherapy Resistance in Prostate Cancer Bone Metastases at Single-Cell Resolution." This project grant funds biomedical research training and investigator-initiated research focused on identifying and...
The National Cancer Institute awarded a $477,674 Project Grant to The Johns Hopkins University (Baltimore, MD) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to conduct molecular imaging research focused on understanding the immune-suppressive tumor microenvironment (TME) in prostate cancer and its response to immune checkpoint inhibitor (CIT) therapy. The research initiative, effective June 1, 2026 through May 31, 2031, will deliver scientific outputs including characterization of hypoxia, metabolic pathways, fibroblast interactions, and extracellular matrix dynamics that create barriers to immune cell infiltration and therapeutic resistance. The project applies advanced molecular and functional imaging methodologies combined with preclinical human and murine prostate cancer models to evaluate the HIF-1A inhibitor PX-478—a compound already in clinical trials—and its capacity to modulate the tumor immune microenvironment and restore responsiveness to immunotherapy. The research deliverables will include mechanistic insights generated through controlled in vitro systems utilizing an MR-compatible cell perfusion platform, characterization studies in castrate-resistant human prostate cancer xenografts, and validation in syngeneic immunocompetent mouse models and human prostate cancer tissue microarrays. These products aim to identify imaging biomarkers and therapeutic targets that can transform prostate cancer from a metastatic castration-resistant disease—the second leading cause of cancer mortality in men—into a condition more responsive to immunotherapeutic intervention by elucidating the spatio-temporal mechanisms underlying immune suppression in the prostate cancer tumor microenvironment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $477.7k | 5/27/26 |