Project Grant F31CA294914

This $153,799 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize the molecular pathways responsible for the initiation and persistence of eosinophilic esophagitis (EoE), a highly inflammatory condition of the esophagus. The University of Utah will conduct RNA sequencing of esophageal tissues during food elimination and reintroduction diets to...

This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of rare genetic variants in the NOD2 gene in the pathogenesis of eosinophilic esophagitis (EOE). The $2,086,360 award to Children's Hospital Medical Center in Cincinnati, OH will fund a 4-year research project to examine how NOD2 variants impair epithelial...

This $784,280 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) will support research to investigate the role of post-transcriptional modifications in regulating esophageal basal cell function and regeneration. The primary recipient, The Trustees of Columbia University in the City of New York, will use a combination of mouse genetics, sequencing, and CRISPR/Cas9...

This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $1,623,261 to Case Western Reserve University to conduct a clinical trial and develop novel molecular technologies for early detection and prevention of esophageal adenocarcinoma. Specifically, the project aims to: 1) demonstrate the efficacy of a non-endoscopic, biomarker-based approach to detect Barrett's esophagus, a precursor to esophageal cancer, in a population...

This $3,130,492 federal Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) supports research to improve understanding of the fundamental biological mechanisms driving the progression of Barrett's esophagus (BE) to esophageal adenocarcinoma (EA), a highly lethal cancer. The project, conducted by Arizona State University, aims to develop computational methods to analyze the spatial structure and cell type diversity in BE tissue biopsies in...

This Cooperative Agreement award from the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research) provides $323,226 to the Regents of the University of Michigan for a project titled "Developing Natural Products to Target IL-8 Signaling and Intercept Progression of Barrett's Esophagus to Esophageal Adenocarcinoma". The project aims to conduct comprehensive research to understand, prevent, and address esophageal adenocarcinoma, a growing health problem with...

This $429,000 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to engineer extracellular vesicles (EEVs) carrying anti-DSG2 single-chain variable fragment (scFv) fusion proteins and miR-155 for therapeutic treatment of head and neck squamous cell carcinoma (HNSCC). The award to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, will support...

This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Case Western Reserve University provides $510,650.00 in funding to investigate the biological factors driving clinical outcomes in HPV-positive oropharyngeal cancer (OPSCC). The research leverages a large cohort of 562 OPSCC patients from the Cleveland area, including 74 individuals from a high-risk subgroup, to explore how factors like HPV status, HPV genotype, and the tumor-immune...

The National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) has awarded Emory University a Project Grant of $156,500.00 to conduct a comprehensive multi-omics investigation of the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The 2-year project, running from August 1, 2025 to July 31, 2027, aims to gain a deeper understanding of the early biological mechanisms driving cachexia, a lethal syndrome affecting up to 80% of advanced cancer patients....

The National Cancer Institute (NCI) awarded a Project Grant under CFDA 93.393 - Cancer Cause and Prevention Research to St. Jude Children's Research Hospital Inc. for the "Evaluation of Cardiovascular Health Outcomes among Survivors 2 (ECHOS-2)" study. The $772,418 grant, awarded on September 1, 2025, will test the efficacy of an eHealth-delivered intervention to improve adherence to cardiomyopathy screening among adult survivors of childhood cancer. The study aims to enroll 350...