Project Grant R03CA304028
- The National Cancer Institute (NCI) awarded a $1,396,152 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the University of Chicago. The grant, with a project period from December 5, 2024 to November 30, 2029, aims to examine the role of the BNIP3 gene and mitophagy (the selective degradation of mitochondria) in muscle atrophy during cancer cachexia, which is prevalent in pancreatic ductal adenocarcinoma (PDAC). The research will utilize genetically engineered mouse...
- This Project Grant award of $432,889 was provided by the National Cancer Institute (NCI), part of the Department of Health and Human Services, under the Cancer Detection and Diagnosis Research Federal Grant Program (CFDA 93.394). The primary objective of this 5-year grant is to apply advanced molecular imaging and metabolotheranostics approaches to better understand and reverse the cachexia (muscle wasting) induced by pancreatic ductal adenocarcinoma (PDAC). The research team at The Johns...
- This federal Project Grant award of $606,839.00, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research to identify gut microbiota that actively deplete intestinal amino acids and evaluate how they affect the tumor microenvironment and cancer progression. The primary awardee is Weill Medical College of Cornell University, a leading academic medical institution with expertise in biomedical research and translational science. The project aims to...
- This Project Grant award of $133,955.00 from the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) program supports research by the Massachusetts Institute of Technology (MIT) to study the role of gluconeogenesis and phosphoenolpyruvate carboxykinase (PEPCK) in cancer cachexia associated with pancreatic ductal adenocarcinoma (PDAC). The project aims to determine how IL6/JAK/STAT signaling induces PEPCK and gluconeogenesis in the liver to promote cancer cachexia...
- This Project Grant award of $129,624 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research at the University of Vermont & State Agricultural College (UVM) to investigate the role of adipose tissue (fat) in facilitating tumor growth and cancer cachexia (muscle wasting). The key objectives are to understand how early changes in adipose tissue metabolism can initiate cancer cachexia, and how substrates released from wasting fat and dietary fats impact...
- The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $285,599 Project Grant to Sinopia Biosciences Inc., a San Diego-based company specializing in computational drug discovery and metabolomics research. The grant will support the development of a metabolomics-enabled AI/ML platform for identifying new treatments to enhance drug sensitivity in cancer. The project aims to leverage high-throughput omics technologies, machine learning, and a chemical library of ~3,300...
- This $204,027 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting the Weill Medical College of Cornell University in expanding single-cell and spatial technologies to link clonal genotypes with phenotypes during cancer evolution. The grant aims to develop advanced single-cell methods that can capture multiple data modalities, including genotypes, transcriptomes, methylomes, and protein expression, to better understand how somatic...
- The National Cancer Institute (NCI), part of the Department of Health and Human Services, awarded a $881,647 Project Grant to Panome Bio Inc. under the Cancer Detection and Diagnosis Research Federal Grant Program (CFDA 93.394). The grant supports research to advance untargeted metabolomics approaches for biomarker discovery in colon cancer. Specifically, Panome Bio is developing novel software and analytical methods to enhance the value and impact of untargeted metabolomics by addressing...
- The National Cancer Institute (NCI) awarded a $645,323 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Washington University to conduct research on the "Mechanism of Acid Signaling in Bone Organ Metastases on Tumor and Myeloid Cell Evolution Towards Immune Suppression and Tumor Progression." The 5-year research project from February 1, 2025 to January 31, 2030 will investigate how breast cancer cells produce factors that induce an acidic bone marrow...
- This Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) provides $219,491 to Emory University to conduct research on mapping the origin of HER2 plasticity in breast cancer. The research aims to gain mechanistic insight into how HER2 expression is dynamically regulated in breast cancer, and explore whether this dynamic HER2 expression can be augmented to improve patient outcomes. The project will employ characterized cell culture...
The National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) has awarded Emory University a Project Grant of $156,500.00 to conduct a comprehensive multi-omics investigation of the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The 2-year project, running from August 1, 2025 to July 31, 2027, aims to gain a deeper understanding of the early biological mechanisms driving cachexia, a lethal syndrome affecting up to 80% of advanced cancer patients. The research will integrate plasma metabolomics and white blood cell DNA methylation analyses to elucidate the systemic metabolic, immune, and inflammatory dysfunctions underlying cachexia development and progression in HNSCC. This integrative, multi-omics approach is expected to uncover new opportunities for timely intervention to address this poorly understood and undertreated complication that significantly reduces cancer patient outcomes and quality of life.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.5k | 7/29/25 |