Project Grant R37CA302718
- This $544,250 federal Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to the University of Nebraska Medical Center (UNMC) will support research to investigate the immune drivers of persistent oncogenic infections, such as oral human papillomavirus (HPV), and their progression to cancer among people living with HIV. The overarching goal is to improve prevention, early detection, and treatment outcomes for infection-related cancers in this high-risk...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $515,812 to The Johns Hopkins University to study the progression of HPV-related oropharynx cancer (HPV-OPC) and how it differs between individuals with and without HIV. The study aims to: 1) characterize the impact of HIV on oral HPV16 persistence, 2) evaluate the performance of oral and blood biomarkers for...
- This federal Project Grant award of $315,000 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research grant program (CFDA 93.121). The funding will support research at The Ohio State University to develop novel antibody therapeutics that target human papillomavirus (HPV) oncoproteins, which are the major drivers of head and neck cancers. The research aims to generate HPV-specific human monoclonal antibodies and...
- This $642,488 Project Grant was awarded on June 10, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the federal Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research conducted by a collaborative partnership between Henry Ford Health and Michigan State University Health Sciences to investigate mechanisms by which human papillomavirus (HPV) drives immune evasion in head and neck squamous cell carcinomas (HNSCC). The research aims...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $544,768 to the University of New Mexico to conduct research focused on understanding the fundamental biological mechanisms of human papillomavirus (HPV)-induced tumors and precancerous lesions. The award aims to elucidate how inhibition of the MEK/ERK signaling pathway can lead to regression of HPV-driven tumors, with the goal of advancing scientific knowledge that can enable improved...
- This federal Project Grant award of $1,899,042.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research at the University of Pittsburgh to analyze high-dimensional genomic datasets to reveal mechanistic insights on divergent outcomes of head and neck cancer. The project aims to use existing public databases of human head and neck squamous cell carcinomas (HNSCC) to identify new mechanisms...
- The federal Project Grant award titled "SMALL MOLECULE INHIBITORS AGAINST HPV-INDUCED OROPHAGEAL CANCERS" was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The $433,125 award, made on August 20, 2025, supports research to screen small molecule libraries for drug candidates that can selectively induce apoptosis in HPV-transformed oral cancer cells. The key...
- This $714,062 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting research at the University of California, San Francisco (UCSF) to investigate the biological mechanisms contributing to racial disparities in oral and head and neck cancer outcomes, particularly among Black patients. The key research objectives are to: 1) develop a tailored RNA prognostic model to enhance oral cancer survival predictions in Black populations by identifying...
- This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at Case Western Reserve University to investigate the role of the SCFFBXO4 E3 ligase in regulating the cyclin D1/CDK4 pathway and metabolic reprogramming in head and neck squamous cell carcinomas (HNSCCs). The $465,404 award, effective January 1, 2025 through December 31, 2029, aims to: 1) determine the ability of p53R172H to cooperate with D1T286A and drive HNSCC in vivo; 2)...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to the Medical University of South Carolina provides $629,179 to optimize treatment for human papillomavirus-associated oropharyngeal cancer in older adults. The 5-year project aims to: 1) characterize the impact of aging and multimorbidity on treatment outcomes and patient preferences, 2) develop and validate a microsimulation model to compare harms vs. benefits of different...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Case Western Reserve University provides $510,650.00 in funding to investigate the biological factors driving clinical outcomes in HPV-positive oropharyngeal cancer (OPSCC). The research leverages a large cohort of 562 OPSCC patients from the Cleveland area, including 74 individuals from a high-risk subgroup, to explore how factors like HPV status, HPV genotype, and the tumor-immune microenvironment may contribute to the observed survival differences among OPSCC patients. The 5-year project, which runs from September 1, 2025 to August 31, 2030, aims to generate insights that could lead to improved prevention, diagnosis, and treatment strategies for this form of cancer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $510.7k | 8/22/25 |