Federal Project Grant Award Summary Vanderbilt University Medical Center received a $2.2 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award funds research to probe mechanistic links between endothelial aging and dementia by developing a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model, referred to as PIPELINING. The project deliverables include:...
Federal Grant Award Summary Vanderbilt University Medical Center received a $149,889 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) beginning September 1, 2025, with a completion date of May 31, 2030. The award supports a discovery-focused research initiative to identify mechanistic associations between epigenetic bone age, frailty measures, and bone imaging findings using artificial intelligence (AI) and deep learning (DL) approaches. The...
Federal Project Grant Award Summary Vanderbilt University Medical Center received a $519,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with completion targeted for April 30, 2028. The grant funds research examining epigenetic age acceleration (EAA) and its differential expression across immune cell populations in people living with HIV (PWH) compared to HIV-negative individuals. EAA—calculated as the...
Federal Project Grant Award Summary Vanderbilt University received a $482,800 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026, through January 31, 2031. The award funds a comprehensive research initiative to investigate sphingolipid-dependent remodeling of mitochondria in aging cells. The research employs live cell imaging, genetics, and quantitative mass spectrometry approaches across two complementary...
Federal Project Grant Award Summary Award Overview Vanderbilt University Medical Center received a $242,489 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 2, 2025, for a project period extending through May 31, 2030. The award supports research examining the proteomic signature of dual decline—the concurrent deterioration of gait and cognitive function in older adults—a condition affecting an estimated 10.2% of the aging...
Federal Project Grant Award Summary Vanderbilt University received a $317,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2026, with a completion date of May 31, 2028. The award funds research examining the relationship between occupational characteristics and labor force participation across the life course and their implications for cognitive functioning in later life. The project specifically aims to...
Federal Project Grant Award Summary The University of Vermont & State Agricultural College received a $664,971 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 15, 2026, with a completion date of November 30, 2030. The project investigates the longitudinal impact of clonal hematopoiesis (CH)—abnormal expansion of blood-forming cell clones in healthy individuals—on aging outcomes and cardiovascular risk prediction. Leveraging the...
Federal Project Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for January 31, 2028. This exploratory grant supports biomedical research directed toward understanding the molecular mechanisms underlying erythropoietin (EPO) deficiency in chronic kidney disease (CKD) and inflammation-related anemia in elderly...
Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $132,705.00 on June 15, 2025, to The Children's Hospital Corporation (Boston Children's Hospital) under the Aging Research program (CFDA 93.866). This award supports research addressing hematopoietic clonal dominance during aging—a condition in which driver mutations cause a limited number of hematopoietic stem and progenitor cell (HSPC) clones to disproportionately contribute to blood cell...
Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Jackson Laboratory $486,750 under the Aging Research program (CFDA 93.866) for a two-year project beginning September 1, 2025, and concluding August 31, 2027. This Project Grant funds research investigating the impact of age-related clonal hematopoiesis (CH)—a condition in which blood-forming stem cells accumulate somatic mutations that provide selective growth advantages—on Alzheimer's disease (AD) pathology onset...
Federal Grant Award Summary
Grant Details: This National Institute on Aging (NIA) Project Grant, awarded under the Aging Research program (CFDA 93.866), provided $105,627.00 in funding to Vanderbilt University for a research project with a performance period from August 5, 2026, through February 4, 2029. The grant supports an NIH F30 predoctoral fellowship-level research initiative investigating clonal hematopoiesis caused by mosaic chromosomal alterations (MCAs).
Research Objectives and Deliverables: The funded research examines how somatic mutations in hematopoietic stem cells contribute to aging-related diseases through clonal expansion of mutated blood cells. The project delivers scientific research and analysis across two primary aims: Aim 1 utilizes longitudinal blood samples from approximately 30,000 individuals in Vanderbilt's BioVU genomic and clinical biobank to quantify how MCA characteristics and environmental factors (including age, sex, body mass index, smoking status, type 2 diabetes, and lipoprotein levels) influence clonal expansion rates, culminating in a predictive model for MCA clonal expansion. Aim 2 expands this analysis to detect MCAs in over one million individuals across multiple genomic biobanks, enabling assessment of genetic and phenotypic associations with clonal expansion rates. The research outputs include longitudinal trajectory analyses, quantitative modeling of mutation contribution, and predictive analytics addressing mechanisms underlying lymphoid and myeloid malignancy risks associated with clonal hematopoiesis in aging populations.