This $470,575 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health program, supports research at Harvard Medical School to develop programmable human artificial chromosomes (HACs) for cell-based therapeutics, diagnostics, and screening. The key objectives are to: 1) program the HAC to induce expression of therapeutic proteins in response to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is for the development of a novel technology called "Precise Area Introduction and Transfection" (PAINT) to enable highly localized and efficient delivery of biomolecules to cells. The $488,753 award, effective September 25, 2024, will fund research to optimize the PAINT system's capability to transiently disrupt cell membranes and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $400,530 to the University of Virginia to develop next-generation "designer nanodiscs" to probe and reprogram membrane biology. The goal is to advance the understanding of how cell membranes regulate the structure, function, and dynamics of proteins involved in key cellular processes like membrane fusion, exosome...
This $588,426 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate how transcription factors efficiently locate and bind to specific DNA binding sites within the crowded nucleus of living cells. The project will employ advanced microscopy techniques to precisely track the 3D diffusion, DNA interactions, and target site discrimination of transcription factors involved in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $833,652 to the University of Connecticut to develop novel DNA-inspired biomaterials for effective intracellular delivery of messenger RNA (mRNA) therapeutics and research tools. The research aims to optimize the biointerface properties of Janus base nanoparticles (JBNPs) using computational molecular design and experimental validation,...
This Project Grant award of $665,616 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of a novel micro-capsule technology to enable high-throughput analysis of millions of live cell-cell interactions in parallel. The technology aims to address a major unmet need in screening functional antibodies and peptides, evaluating ligand-receptor specificity, and determining cell adhesion affinities....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
This federal Project Grant award of $324,998 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program supports Rejuvenation Technologies Inc. (RTI) in developing advanced therapeutic technologies for in vivo delivery of mRNA to stem and progenitor cells. The key objectives of this award are to: 1) generate a library of rationally designed peptides for targeting three progenitor cell types, 2) utilize computational...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), provides $864,515 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on the functional characterization of cell surface RNA biology. The project aims to explore three key hypotheses related to the molecular, biochemical and biophysical activities of cell surface RNA-binding...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is providing $651,384 to Trustees of Boston University to develop a self-amplifying RNA-based synthetic nanobody platform for next-generation therapeutics. The research aims to transform antibody-based therapeutics by integrating rapid, scalable nanobody discovery and...