Project Grant R21EB036741

Award Date 12/3/24
Completion Date 11/30/26
Dollars Obligated $223K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
ROXBURY CROSSING, MA 02120, USA
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The key objectives are to: 1) use the HAC to program inducible expression of multiple therapeutic proteins in response to inflammation, with the aim of treating autoimmune diseases, and 2) build a HAC-based sensor cell line for screening associated with the innate immune response. The award will enable the awardee, President and Fellows of Harvard College (doing business as Harvard Medical School), to rigorously address challenges in robust, stable, and regulated expression of multiple transgenes and genetic circuits within the HAC platform. This research seeks to enhance the ability to explore cells through controlled genetic composition at higher throughput, with applications in disease sensing and therapeutic development.

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