Project Grant DP2NS148743
- The National Institute of Child Health and Human Development (NICHD) awarded a $451,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the therapeutic potential of maternal breast milk components for preterm white matter injury (WMI). The key objectives are to: 1) Perform high-throughput screening of breast milk components to identify pro-myelinating compounds, and 2) Test...
- This $691,935 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders supports research to develop quantitative diffusion MRI methods for predicting neurodevelopmental outcomes in infants with hypoxic ischemic brain injury. The project aims to analyze diffusion MRI data from two large datasets - the High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL)...
- The federal Project Grant award of $1,440,000.00 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310), awarded to Northwestern University on August 1, 2025, aims to develop a transformational approach to reprogram brain cells and enhance their resilience against a broad array of neurodevelopmental diseases. The project, titled "Perinatal Brain Therapeutics: A High Throughput Biology Approach to Build Next...
- This $635,386 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Duke University to investigate the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The research aims to elucidate how complications of prematurity, such as intestinal perforation, can lead to diffuse myelination deficits and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,724 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, San Francisco (UCSF) on January 23, 2025. The project, titled "Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury", aims to use computational approaches to identify altered...
- The National Institute of Child Health and Human Development (NICHD), a civilian agency within the U.S. Department of Health and Human Services, awarded a $615,478 Project Grant to the University of Washington on June 18, 2025. The grant is part of the Child Health and Human Development Extramural Research program (CFDA 93.865) and aims to optimize neuroprotective strategies for hypoxic-ischemic encephalopathy (HIE) in low- and middle-income countries. The University of Washington will develop...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health National Institute of Child Health and Human Development provides $769,916 to Emergent Biotechnologies LLC for research into a novel therapy for preeclampsia. The funding supports Phase 1 of developing and characterizing a handle region peptide as an innovative treatment for preeclampsia under the Child Health and Human Development Extramural Research program (CFDA 93.865). Phase 1 work will...
- This Project Grant award, totaling $547,846 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to optimize and characterize small molecule GPR17 antagonists for potential treatment of multiple sclerosis (MS). The research will focus on understanding the role of the GPR17 receptor in oligodendrocyte maturation and remyelination, with the goal of...
- This federal Project Grant award of $238,500 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research conducted by the University of California, San Diego (UCSD) to develop a new phosphorodiamidate morpholino oligonucleotide (PMO) therapeutic for treating Alzheimer's disease (AD). The research aims to create a highly effective PMO that can...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
This Project Grant award from the U.S. Department of Health and Human Services (HHS) National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $1,476,000.00 to the University of California, San Francisco (UCSF) to develop a therapeutic pipeline for preterm white matter injury (PWMI). The key products and services to be delivered include: Identification of remyelinating compounds that can promote oligodendrocyte differentiation and myelination, using a high-throughput in vitro screening platform called Binary Indicant for Myelination using Micropillar Arrays (BIMA). Validation and testing of promising remyelinating compounds in vitro and in a murine chronic hypoxia model of PWMI. Completion of a Phase I/Ib clinical trial to evaluate the safety and pharmacokinetics of the remyelinating compound clemastine in preterm neonates with PWMI. This award aims to develop potential therapeutic interventions to address the significant unmet need for treatments for PWMI, which is the most common type of brain injury in premature infants and leads to adverse neurological outcomes. The project period runs from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 7/31/25 |