Project Grant DP2NS148744
- This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This $449,228 Project Grant from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will enable Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for large-scale, chronic extracellular neural recording and stimulation in human brain organoids. The project aims to 1) create advanced biological assay chambers to support chronic electrophysiology while maintaining organoid health, 2) develop...
- This federal Project Grant award of $460,500 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is aimed at developing novel bioprinting methodologies for the production of human stem cell-based organoids. The key objectives are to: 1) Create a customized bioink formulation using proteins, polysaccharides, and functionalized nanoparticles to foster the...
- This federal Project Grant award of $629,031.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel label-free, live-cell classification system for neural stem cell activation state. The award aims to leverage fluorescence-lifetime imaging (FLIM) and analysis of cellular metabolites and autofluorescence to non-invasively track neural...
- The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute in Seattle, WA. The award, spanning September 2024 to September 2027, aims to develop two "exa-scale" (extremely high-throughput) tissue readout methods to transform the study of the brain. The first method will enable highly multiplexed molecular mapping of individual proteins across entire brains at the...
- This $1,323,950 Project Grant was awarded on August 1, 2025 by the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant was awarded to Clemson University to support research focused on developing nanoparticle-based delivery methods to enable the targeted transport of RNA-based therapeutics across the blood-brain barrier. The overarching goals are to 1) increase the stability of RNA in vivo, 2) control...
- This Project Grant award of $200,000.00 was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to Northwestern University. The award supports research to elucidate the neural basis of hallucinations in Parkinson's disease. The project will be conducted at Northwestern University in Evanston, Illinois from July 1, 2025 to June 30, 2027. As a leading academic research institution, Northwestern University has an extensive track record...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $381,375.00 to New York University to develop genetic strategies to study a novel disinhibitory system in the cortex. Specifically, the project aims to gain a detailed understanding of how top-down and bottom-up signals are integrated in the superficial...
- This federal Project Grant award for $1,493,271 was made by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) on May 1, 2024. The award will support a 3-year research project led by The Washington University to conduct "Precision Brain Mapping and Deep Phenotyping in Pediatric Brain Tumor Patients." The key objectives of the research are to: 1) Determine the relationship between long-term cognitive outcomes and functional brain...
The federal Project Grant award of $1,440,000.00 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310), awarded to Northwestern University on August 1, 2025, aims to develop a transformational approach to reprogram brain cells and enhance their resilience against a broad array of neurodevelopmental diseases. The project, titled "Perinatal Brain Therapeutics: A High Throughput Biology Approach to Build Next Generation RNA Precision Medicines," seeks to stabilize electrical activity in the brain before permanent damage can occur in children with severe neurodevelopmental diseases, such as treatment-resistant epilepsy. The research will combine the university's proven RNA therapeutics approach to stabilize excitotoxicity pathways with advanced high-throughput biology techniques to provide an immediately available and broadly applicable RNA therapeutic solution. The project is scheduled for completion by July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 7/25/25 |