The National Institutes of Health (NIH) Office of the Director awarded a $1,330,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Salk Institute for Biological Studies in La Jolla, CA. The award, which runs from September 2024 to August 2029, will fund the development of a "Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity" research project. The primary objectives are to (1) determine if acute degradation of specific...
The University of California, San Diego will receive $3,868,694 under a three-year Project Grant from the National Institute on Aging, part of the National Institutes of Health, to develop selective amyloid-responsive fluorescent probes. The goal is to uncover design principles for probes that can selectively detect aggregated forms of alpha-synuclein or tau versus amyloid-beta in solution and tissue. The university will also develop a method to characterize the distribution of amyloidogenic...
This federal Project Grant award, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports the development of experimental and theoretical frameworks for optimizing targeted protein degrader compounds. The $492,000 award, spanning July 2024 to June 2029, allows Professor Ferguson at the University of California, San Diego to evaluate the kinetic parameters of targeted protein degradation across the kinome and develop new...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,181,250 in funding to the Seattle Institute For Biomedical And Clinical Research to develop small molecule inhibitors of the MSUT2 protein as a potential therapeutic approach for treating tauopathy disorders such as frontotemporal lobar degeneration, Alzheimer's disease, and related conditions. The project aims to optimize potent and brain-penetrant MSUT2 inhibitors and demonstrate...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate how chaperone proteins mediate proteasomal degradation of substrates. The principal investigator will use a multi-disciplinary approach, including in vitro characterization and cryo-electron microscopy, to study how the HSP70/CHIP/BAG-1 chaperone complex affects the various steps of proteasomal...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rezigene, LLC provides $349,854 to develop an anti-proteotoxicity therapy for neurodegenerative diseases. The research aims to discover novel molecular targets and test new small molecule compounds that can harness the cellular defense system to prevent and treat neurodegenerative diseases associated with protein misfolding and aggregation, such as Alzheimer's disease, frontotemporal dementia, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) seeks to advance heterobifunctional degraders that induce targeted protein degradation through the ubiquitin proteasome pathway. The $316,226 award aims to optimize the structure and amphiphilicity of peptide-based proteolysis targeting chimeras (PEPTACs) to improve their catalytic activity and enhance target protein degradation. The...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research to investigate the interaction between the AAA+ disaggregase Hsp104 and the Hsp70 molecular chaperone system. The $153,488 award to the Regents of the University of California, San Francisco aims to use biochemical and structural analysis techniques, including cryo-EM, to elucidate how Hsp70 contributes...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $402,500 to Duke University over a 5-year period beginning July 15, 2024 to develop programmable, isoform-selective proteome editing systems. The research aims to create peptide-guided enzymes that can post-translationally modify and degrade target proteins, including enabling selective targeting of mutant protein variants and...