The National Institute of General Medical Sciences (NIGMS) awarded a $1,189,314 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Washington University to elucidate the roles of protein disaggregases and develop enhanced disaggregases to counter diverse protein-misfolding disorders. This 5-year grant, effective September 1, 2024, aims to better understand how cells maintain protein homeostasis, how proteostasis fails, and how protein disaggregases can be applied to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $459,006 to Marquette University to study the role of molecular chaperone systems in managing protein aggregation associated with neurodegenerative and systemic diseases. The 3-year project aims to define how the HSP110 and HSP104 chaperone systems work together to disassemble different types of protein aggregates, including...
This federal Project Grant award, valued at $425,803.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research at the University of Mississippi to elucidate the structural attributes and functional roles of the cytosolic heat shock protein 70 (HSP70) in maintaining cellular integrity and stress response. Key objectives include investigating HSP70's lectin-like capacity to...
This $100,620 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the mechanisms that regulate proteasome assembly in eukaryotic systems. The research aims to uncover the mechanisms controlling: (1) proteasome subunit gene expression, (2) assembly dynamics of the proteasome core particle and regulatory particle, and (3) post-translational modifications of the...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to resolve the protein interaction network that drives autolysosomal tethering, a critical step in the autophagy process. The $1,150,541 award, with a project period from July 1, 2024 to April 30, 2029, will fund research conducted by the University of Missouri System to determine the molecular interactions that enable...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $153,488 to The Regents of the University of California, San Francisco (UCSF) to advance the understanding of how the AAA+ disaggregase protein Hsp104 interacts with the Hsp70 molecular chaperone system to target and solubilize toxic protein aggregates associated with neurodegenerative diseases. The research aims to define the...
This $597,573 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to provide atomic-level insights into the structure, dynamics, interactions, and function of large protein and protein-DNA systems that are significant in biology and human health. The research focuses on two key areas: (1) nucleosomes and large nucleosome arrays mimicking chromatin, and their complexes with...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $534,160 to support research on the molecular mechanisms underlying protein function. The key focus areas include: Elucidating the mechanisms by which ion transport proteins, such as TMEM175, CLC, IP3Rs, and CLN7, recognize and transport ions across cellular membranes, as well as how their activities are regulated. Investigating...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $959,190.00 to the University of North Carolina at Charlotte to investigate the role of Hsp70 phosphorylation in proteostasis and the heat shock response. The research aims to study how phosphorylation of the Hsp70 molecular chaperone impacts its function in yeast, particularly regarding the formation of reversible...
This Project Grant award for $380,540, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to decipher novel principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The research aims to define new protein substrates and peptide motifs required for lysosomal delivery, determine the functional impact of methyl-driven lysosomal proteolysis on cellular metabolic...