This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,250 to the University of California, San Diego (UCSD) to develop new tools to image the tau protein and its role in Alzheimer's disease. The goal is to create a peptide-based probe that can measure tau in its different forms - soluble, liquid-liquid phase separation, and liquid-solid phase separation - within living cells using aggregation-induced emission (AIE) technology. This...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $238,500.00 to the University of California, San Diego (UCSD) to develop a new phosphorodiamidate morpholino oligonucleotide (PMO) therapeutic to treat Alzheimer's disease. The project aims to create a PMO that can efficiently escape endosomes and selectively target the amyloid precursor...
This federal Project Grant award of $437,875.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) will support a comprehensive study to quantify the lifetimes of neurovascular proteins in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The primary objectives are to: 1) employ stable isotope labeling, vessel isolation, and mass spectrometry proteomics to measure neurovascular protein lifetimes...
The National Institute on Aging (NIA) awarded a 3-year, $4,618,216 Cooperative Agreement (CFDA 93.866 - Aging Research) to the University of California, San Diego (UC San Diego) to develop a novel microtubule-stabilizing drug candidate, CNDR-51997, for the treatment of Alzheimer's disease and related neurodegenerative "tauopathy" conditions. The primary objectives are to advance CNDR-51997 through IND-enabling studies and submit an Investigational New Drug (IND) application to the FDA....
The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), has awarded a $2,112,826 cooperative agreement to the University of California, San Diego (UCSD) to advance a CRISPR-based therapeutic for Alzheimer's disease (AD) towards pre-IND stage. The project aims to determine the optimal gene-editing combination to edit the APP gene, which plays a central role in AD pathogenesis, and shift the APP cleavage pathway from pathologic to physiologic. UCSD will evaluate...
The University of Illinois has been awarded a $1,870,822 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop new super-resolution fluorescence microscopy techniques. The goal is to achieve ultra-high resolution imaging of native amyloid-alpha receptors (AMPARs) in brain slices to study synaptic plasticity in both healthy and tauopathy conditions. The research will utilize multi-color imaging and digital image reconstruction methods to isolate...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,929,011 to The Regents of the University of California, San Francisco to conduct a longitudinal, multimodal imaging study. The study aims to elucidate the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The research will identify the earliest manifestations of neural circuit hyperexcitability that predict the...
This $3,845,311 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of California, San Diego (UCSD). The award aims to use induced neurons (iNs) derived from mild cognitive impairment (MCI) patients to investigate the early determinants and pathogenesis of Alzheimer's disease (AD). The project will integrate polygenic risk scores for AD with multi-omic profiling of MCI patient-derived iNs to better understand the...