Project Grant DP2GM171031
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California Santa Cruz $234,750 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a de novo binder-luciferase platform for multiplexed protein detection in Western blots and lateral flow assays. The project will replace antibody-based detection reagents with computationally designed, thermostable de novo...
- The National Institutes of Health Office of the Director awarded $672,000 to the University of California, San Diego on August 24, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop synthetic uniRFP-based biosensors (SUBs) for real-time detection of small molecules in living systems. The award funds creation of an experimental platform and predictive machine learning algorithm that engineers the binding pocket of UNAG, a naturally occurring eel fluorescent protein, to...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $360,125 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new luciferin substrates that extend bioluminescent emission into the near infrared spectrum and corresponding luciferases that efficiently utilize these substrates. The project addresses limitations in current bioluminescence assays and imaging methods by engineering luciferins...
- The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $714,870 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop bifunctional small molecules for biosensing and continuous enzyme evolution. The project addresses two bottlenecks in directed enzyme evolution: the low throughput of classical analytical methods, which explore only 10² variants per round, and the labor-intensive manual operations between...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Irvine a $1.89 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2029. The research initiative focuses on developing molecular lanterns—ultra-small ribonucleic acid (RNA) tags that assemble split luciferases—to enable real-time visualization and tracking of multiple RNA transcripts...
- The National Institute of General Medical Sciences awarded $430,109 to The Regents of the University of California, operating Lawrence Berkeley National Laboratory, on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop deeply subwavelength near infrared imaging technology using avalanching nanoparticles. The project addresses fundamental limitations of live-cell optical microscopy by creating avalanching nanoparticles (ANPs) that upconvert incident...
- The National Institutes of Health Office of the Director awarded the University of California, Berkeley $2,397,234 under the Trans-NIH Research Support program (CFDA 93.310) on July 15, 2026, for the acquisition and installation of a Nanoscribe Quantum X Align system in the Marvell Nanofabrication Laboratory. The instrument enables three-dimensional micro- and nano-printing with sub-micron resolution and sub-100-nanometer feature control across centimeter-scale areas. It supports two-photon...
- The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $779,000 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop CRISPR-CHROMEXM, a next-generation imaging platform for direct visualization of single-molecule gene regulation during vertebrate embryogenesis. The project will integrate catalytically inactive Cas9 with the existing ChromExM (chromatin expansion microscopy) method to...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $1,733,072 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multi-resolution open-top light-sheet expansion microscopy system. The project will advance 3D microscopy for high-throughput imaging of expanded tissues with ultra-high resolution—sub-150 nanometer...
- The National Institutes of Health Office of the Director awarded The Broad Institute, Inc. $831,250 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop novel nanoprobes and advanced imaging techniques that extend single-molecule fluorescence microscopy capabilities in living cells. The project addresses fundamental limitations in visualizing G-protein-coupled receptor (GPCR) signal transduction. Current single-molecule imaging methods photobleach within...
The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $731,646 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to design synthetic luciferase–substrate pairs for bioluminescent bioimaging and biosensing. The project, titled "Designing Biological Light from Scratch: A New Paradigm for Bioimaging and Biosensing," combines de novo protein design, synthetic chemistry, and deep learning to engineer new-to-nature luciferases and synthetic substrates—termed "neoluminescence"—that do not require external excitation light and enable real-time visualization across micro to macro scales. The work will generate synthetic substrates with high quantum yield and distinct emission colors, develop deep learning models to guide design of compact, thermostable de novo luciferases tailored to each substrate, and deliver a neoluminescent toolkit for multiplex monitoring of biological processes. Place of performance is Santa Cruz, California. The award runs through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/27/26 | ||
| Not listed | $731.6k | 8/26/26 |