Project Grant R01GM166815
- The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $731,646 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to design synthetic luciferase–substrate pairs for bioluminescent bioimaging and biosensing. The project, titled "Designing Biological Light from Scratch: A New Paradigm for Bioimaging and Biosensing," combines de novo protein design, synthetic chemistry, and deep learning to engineer...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $444,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop secreted genetically encoded fluorescent biosensors for in vivo extracellular imaging. The project will create a toolkit of biosensors across four research areas: imaging extracellular matrix structures by conjugating fluorescent proteins to lectins and...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative...
- The National Institute of General Medical Sciences awarded The University of Chicago $150,104 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms underlying the repeated functional evolution of bioluminescent proteins derived from haloalkane dehalogenases. The research examines how a new catalytic mechanism—monooxygenase-catalyzed light production—repeatedly evolved in distantly related taxa by recruiting...
- The National Institute of General Medical Sciences awarded the University of Massachusetts $2.35 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate non-specific electrostatic interactions of biological macromolecules in physiological and pathological processes. The project examines how highly charged polycationic and polyanionic biomacromolecules — including heparin, neutrophil extracellular traps, and other polymeric species —...
- The National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) awarded a $448,536 project grant to the University of North Carolina at Charlotte (UNC Charlotte) to investigate the luminescence properties of protein-metal nano-complexes. The research aims to elucidate the common luminophore motif in these materials, which have diverse applications in imaging, nanomedicine, and sensing. The 3-year project will combine spectroscopy...
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Massachusetts Lowell $431,337 on August 20, 2026, for the BRITE (Biotechnology Research, Innovation, Training, and Education) Predoctoral Training Program under CFDA 93.859 (Biomedical Research and Research Training). The BRITE program delivers predoctoral training in biotechnology and biomedical sciences to eight students per...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $460,625 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to uncover fundamental principles of transcriptional regulation in the model bacterium E. coli. The project systematically measures the function and occupancy of transcription factors to parameterize a predictive model of gene regulation. The research exploits a library of E. coli strains...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover novel antimicrobial molecules from clostridial biosynthesis. The project characterizes cobalamin-dependent radical S-adenosylmethionine enzymes fused with non-ribosomal peptide synthetase adenylation domains found in clostridial genomes. The recipient will conduct biochemical characterization of these...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Irvine a $1.89 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2029. The research initiative focuses on developing molecular lanterns—ultra-small ribonucleic acid (RNA) tags that assemble split luciferases—to enable real-time visualization and tracking of multiple RNA transcripts...
The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $360,125 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new luciferin substrates that extend bioluminescent emission into the near infrared spectrum and corresponding luciferases that efficiently utilize these substrates. The project addresses limitations in current bioluminescence assays and imaging methods by engineering luciferins with improved substrate access, cell permeability, chemical stability, and photophysical properties to enhance light emission for small animal imaging and drug discovery applications. Work is performed in Worcester, Massachusetts, with a performance period through March 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $360.1k | 7/27/26 |