Project Grant DP2GM170824
- The National Institute of General Medical Sciences awarded $338,892 to the University of Illinois on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for organometallic chemistry research on nickel enzymes. The project focuses on developing catalytic and functional mimics of acetyl-coenzyme A synthase (ACS) and [NiFe] hydrogenase through the design of flexible multidentate ligands with mixed hard/soft donor atoms. The research aims to detect and...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $412,201 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how metabolic microenvironments direct immune cell plasticity and function. The research project develops and applies an organotypic array for culture in live-cell environments (ORACLE), a micropatterned 3D hydrogel platform with functional vasculature that enables spatial and...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded $259,270 to the University of Wisconsin–Madison on August 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). This Project Grant (R01GM170992) supports development of data infrastructure, analytic methods, and forecasting models to measure how federally funded biomedical research translates into improved health...
- The National Institutes of Health Office of the Director awarded $415,538 to the University of Wisconsin System, University of Wisconsin - Madison Division, on August 5, 2026, under the Trans-NIH Research Support program (CFDA 93.310), a Project Grant (R21AI200047). The award funds research on regulation of neutrophil heterogeneity and activation state using human induced pluripotent stem cell-derived neutrophils (iNeutrophils). The work employs single-cell multi-omics and imaging to...
- The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $714,870 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop bifunctional small molecules for biosensing and continuous enzyme evolution. The project addresses two bottlenecks in directed enzyme evolution: the low throughput of classical analytical methods, which explore only 10² variants per round, and the labor-intensive manual operations between...
- The National Institutes of Health Office of the Director awarded the University of Wisconsin System $1,038,908 on July 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire a SCIEX ZenoTOF 7600+ time-of-flight mass spectrometry system with novel fragmentation capabilities at the University of Wisconsin–Madison campus in Madison, Wisconsin. The instrument will serve 23 investigators conducting research in quantitative and investigational proteomics, functional glycomic...
- This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $431,400 to North Dakota State University to develop nickel-based catalysts for alkyne hydrofunctionalization reactions. The research aims to leverage directing groups to enhance the efficiency, regioselectivity, and stereoselectivity of nickel-catalyzed alkyne hydroamination and hydroetherification reactions. The project includes...
- The National Institute of General Medical Sciences awarded $429,203 to the University of Wisconsin–Madison on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R35GM161252) to develop optically enhanced NMR methods for high-resolution analysis of biomolecular structure, dynamics, and interactions at sub-micromolar sensitivity under physiologically relevant conditions. The award supports integrated research combining NMR method...
- The National Science Foundation Division of Chemistry awarded the University of Wisconsin–Madison $600,000 on August 1, 2026, for modular chemocatalysts research under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Jennifer Schomaker's team is developing inexpensive silver-based catalysts to enable direct, selective conversion of carbon-hydrogen (C–H) bonds into carbon-nitrogen (C–N) bonds in organic molecules within a single step and in high yields. The catalysts...
- The National Science Foundation Division of Industrial Innovation awarded a $550,000 Project Grant to the University of Wisconsin-Madison through the Engineering federal grant program (CFDA 47.041) to support research titled "ELECTROCHEMICAL TECHNOLOGIES FOR PHARMACEUTICAL SYNTHESIS VIA NICKEL-CATALYZED ARYL-ALKYL CROSS-COUPLING." This three-year award beginning in August 2021 will fund the development of electrochemical technologies for pharmaceutical synthesis using...
The National Institutes of Health Office of the Director awarded the University of Wisconsin–Madison $714,809 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to discover and engineer nickel biocatalysts for precise tailoring of therapeutics. The research develops enzymes that control nickel-catalyzed reactions, merging nickel's reaction versatility with enzymatic selectivity. The project pursues three synergistic innovations: a bioinformatic pipeline to discover and characterize new nickel enzymes from nature; engineering of enzymes to bind nickel-containing cofactors instead of the standard nicotinamide adenine dinucleotide cofactor, potentially expanding known nickel enzymes from ten to hundreds; and directed evolution of nickel catalysts that perform site-selective chemistry on complex bioactive compounds including sugar derivatives and natural products. Preliminary results have identified a previously unknown nickel enzyme with promising biocatalytic properties that performs chemistry on sugars. Performance of work occurs in Madison, Wisconsin, with a period of performance from September 1, 2026, through August 31, 2031. The award is a Project Grant, an assistance type subject to NIH peer review for scientific and technical merit and program relevance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $714.8k | 9/1/26 |