Federal Grant Award Summary

The National Institutes of Health Office of the Director awarded University of Wisconsin-Madison $1,038,908 through the Research Infrastructure Programs (CFDA 93.351) on July 1, 2026 to acquire a SCIEX ZenoTOF 7600+ time-of-flight mass spectrometry system. This high-resolution analytical instrumentation addresses critical analytical limitations in current mass spectrometry capabilities, including insufficient sensitivity, quantitative accuracy constraints, and low duty cycles that eliminate up to 90% of ions prior to analysis. The instrument will support 23 investigators across multiple research domains including quantitative and investigational proteomics, functional glycomic analysis, structural characterization of bioactive molecules, pharmacokinetic and pharmacodynamic analyses, and natural product discovery and metabolomic profiling with applications to human health and disease research.

The ZenoTOF 7600+ system incorporates novel fragmentation and ion selection capabilities designed to enhance analytical sensitivity in proteomic, glycoproteomic, and small molecule analyses while providing the most effective commercial solution for accurate absolute biomolecular quantitation. The Research Infrastructure Programs, administered through the Office of Research Infrastructure Programs (ORIP) in the Division of Program Coordination, Planning, and Strategic Initiatives, primarily funds acquisition of cutting-edge biomedical research instruments and development of research resources at eligible nonprofit and public institutions. The award period extends through June 30, 2027.