Project Grant R35GM161252
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $413,001 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational systems for analyzing single-cell and spatial transcriptomics experiments. The recipient will create computational methods to improve downstream analysis of gene-expression data from single-cell and spatial transcriptomics experiments, which measure genome-wide expression in...
- The National Institute of General Medical Sciences awarded The Medical College of Wisconsin, Inc., a Project Grant totaling $566,169 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds development of novel site-directed spin labeling electron paramagnetic resonance (SDSL-EPR) technologies and application of these and other biophysical methods to elucidate molecular mechanisms of G protein-coupled receptor (GPCR) signaling selectivity and...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $412,201 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how metabolic microenvironments direct immune cell plasticity and function. The research project develops and applies an organotypic array for culture in live-cell environments (ORACLE), a micropatterned 3D hydrogel platform with functional vasculature that enables spatial and...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $3.654 million on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support the National Center for Quantitative Biology of Complex Systems, which accelerates multi-omic quantitative biology research by providing researchers integrated access to mass spectrometry, lipidomics, and metabolomics technologies for comprehensive proteome, lipid, and metabolite...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $580,507 on May 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms governing midbody remnants in intercellular RNA communication. Over the five-year period of performance through February 28, 2031, the research will characterize the molecular cargo of midbody remnants—large extracellular vesicles released during cell division—across diverse...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded $259,270 to the University of Wisconsin–Madison on August 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). This Project Grant (R01GM170992) supports development of data infrastructure, analytic methods, and forecasting models to measure how federally funded biomedical research translates into improved health...
- The National Institute of General Medical Sciences awarded $414,305 to the University of Wisconsin–Madison on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced statistical genetics tools for drug target discovery and treatment optimization. The award funds a five-year project through February 28, 2031, with work performed in Madison, Wisconsin. The research will address methodological challenges in Mendelian randomization and causal...
- The National Institute of General Medical Sciences awarded the University of Wisconsin System $418,331 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for advanced statistical methods for microbiome data analysis. The award funds development of innovative batch-effect correction methods, meta-analysis techniques, and robust causal-inference tools to address methodological gaps in microbiome research. The recipient will develop and disseminate...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $310,405 on September 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for development of causal inference methods for complex biomedical data. The project develops distributional balancing methods to support causal inference in critical care settings where standard assumptions—no unmeasured confounding, single-time exposures, and ideal measurement—rarely hold. The...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and...
The National Institute of General Medical Sciences awarded $429,203 to the University of Wisconsin–Madison on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R35GM161252) to develop optically enhanced NMR methods for high-resolution analysis of biomolecular structure, dynamics, and interactions at sub-micromolar sensitivity under physiologically relevant conditions. The award supports integrated research combining NMR method development with applications to chaperone–client protein complexes. The work addresses gaps in structural biology by enabling conformational analysis of soluble biomolecular systems under liquid-state conditions without sample freezing and by measuring atomic-resolution dynamics of fast local motions on timescales faster than milliseconds—capabilities beyond current cryo-EM and cryo-ET approaches. The primary methodological focus is increasing NMR sensitivity through further development of a hyperpolarization approach to overcome the technique's traditional requirement for high-concentration (>100–200 μM) samples, thereby expanding applicability to biomedically relevant mechanisms. Performance occurs in Madison, Wisconsin. The period of performance runs through June 30, 2031. The assistance type is a Project Grant, a component of NIGMS's MIRA (Maximizing Investigators' Research Award) program, which the source indicates NIGMS prioritizes over R01 awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.2k | 8/20/26 |