Project Grant DP2GM164606
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $980,943 to Purdue University from August 1, 2025 to July 31, 2029. The project aims to develop new artificial intelligence (AI) tools that can automatically interpret cryogenic electron microscopy (cryo-EM) data into accurate 3D molecular structures and validate those structures for errors. The key objectives are: (1) developing deep learning methods to...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This $380,785 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University. The grant supports research to develop new algorithms for quantitatively recovering protein conformational ensembles from cryogenic electron microscopy (cryo-EM) data. The key objectives are to accelerate computational methods for matching simulated and experimental cryo-EM images, and to utilize...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel high-throughput machine learning approaches to study cell population-wide differences in subcellular object morphology, conformations, and organization using cryo-electron tomography (cryo-ET) data. The $371,427 award, granted on June 10, 2025, will support Carnegie Mellon University in addressing...
- This Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program provides $250,000 to the University of California, Davis to develop fast and robust algorithms for 3D molecular structure reconstruction from cryo-electron microscopy (cryo-EM) data. The project aims to overcome the computational barriers limiting the widespread adoption of cryo-EM by creating new algorithms for image alignment and molecular...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded The Trustees of Columbia University in the City of New York a $1,200,000 Project Grant on March 15, 2025 to develop and apply a method of time-resolved cryo-electron microscopy (cryo-EM) to diverse biological molecules of medical importance. The project aims to use newly designed PDMS-based microfluidic chips to apply the time-resolved cryo-EM sample preparation technique, which has been...
- This Project Grant award for $1,440,905, awarded on September 1, 2025 by the National Institute of Environmental Health Sciences, funds research to develop improved computational methods for predicting protein-protein interactions (PPIs). The project aims to create complementary approaches that can accurately predict both stable and transient PPIs, including those involving peptide-binding domains and post-translational modifications - areas that are challenging for existing PPI prediction tools...
The National Institutes of Health (NIH) awarded a $1,476,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Princeton University for a project titled "Algorithms and Software for Biomolecular Structure Determination at the Proteome Scale". The objective of this 3-year project, starting on September 9, 2025 and ending on August 31, 2028, is to develop novel artificial intelligence (AI) and machine learning (ML) methods to address critical challenges in cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) image processing. The goal is to advance a new paradigm of biomolecular structure determination that can operate at the proteome scale, enabling high-throughput and high-resolution analysis of complex biological systems. The project aims to integrate prior structural information from sequence and structural databases with cryo-EM and cryo-ET data, leveraging the strengths of both data-driven and knowledge-based approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 9/9/25 |