This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $653,693 to Emory University to conduct structural studies of the HIV-1 virus. The research aims to gain a detailed understanding of the molecular mechanisms underlying HIV-1 assembly, maturation, and entry into host cells. The work will leverage advanced cryo-electron microscopy and tomography techniques to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $236,292 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Tufts University School of Medicine to isolate and characterize the structures of key herpes simplex virus (HSV) glycoprotein complexes involved in viral entry. The two-year grant, running from February 1, 2025 to January 31, 2027, will leverage advanced cryo-electron microscopy techniques to obtain high-resolution structural...
This $298,350 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on the intracellular entry pathway utilized by herpes simplex virus (HSV) in epithelial cells. The goal is to demonstrate that HSV transits the Golgi complex prior to reaching the nucleus during successful cell entry, providing critical insights into the viral entry process. The research employs...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $215,810 to support research on the mechanisms by which the herpes simplex virus type 1 (HSV-1) degrades host proteins in neurons to promote viral gene expression and modulate viral latency/reactivation cycles. The project aims to identify the specific host proteins degraded in neurons following HSV-1...
This Project Grant award of $375,430 from the National Institutes of Health's Biomedical Research and Research Training program (CFDA 93.859) supports research to understand how viral pathogens hijack cellular DNA replication and repair machinery for their own benefit. The goal is to develop novel tools and methodologies to interrogate how viruses modulate host genome stability signals, localize to cellular DNA break sites, and tether themselves to these sites for long-term persistence. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $223,300 to Emory University to develop novel antiviral compounds targeting the HIV capsid protein. The primary goals are to synthesize and characterize analogs of lead compounds that can bind and inhibit the HIV capsid, including mutations that confer resistance to the recently approved drug lenacapavir. The...
This $1,736,846 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to gain new insights into the assembly and maturation of deltaretroviruses, a class of complex retroviruses associated with lymphoid leukemias in humans and cattle. The research team at the University of Minnesota will apply advanced imaging techniques such as cryo-electron microscopy, super-resolution...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $370,190 to San Diego State University Foundation to conduct direct measurements of RNA virus nucleocapsid self-assembly and disassembly. The research aims to uncover potentially universal mechanisms of these essential viral processes across multiple RNA-packaging virus types, with a focus on the role of RNA sequence and structure....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $497,998 to the University of Virginia to support research on the role of mitochondrial/endoplasmic reticulum (ER) contact sites in regulating innate immune responses to viral infections. The research aims to examine how these contact sites, known as MERCs, stimulate the release of mitochondrial DNA (mtDNA) during infection by...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $194,616 to Emory University for the development of virus-like particles (VLPs) to support HIV-1 cure strategies. The key objectives are to: 1) Use VLPs to deliver the HIV-1 Tat protein as a latency reversing agent to reactivate latent HIV-1 proviruses, and 2) Utilize VLPs to deliver the Cas12k enzyme fused to HIV-1...