Project Grant R01GM151775

Award Date 7/15/24
Completion Date 5/31/28
Dollars Obligated $1.7M
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Minnesota, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $370,190 to San Diego State University Foundation to conduct direct measurements of RNA virus nucleocapsid self-assembly and disassembly. The research aims to uncover potentially universal mechanisms of these essential viral processes across multiple RNA-packaging virus types, with a focus on the role of RNA sequence and structure....
This $987,566 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will support research on virus self-assembly, from test tube to cell cytoplasm. The research aims to elucidate the fundamental differences between in vitro and in cellulo viral processes by progressively adding molecules that play key roles in the viral life cycle. This will be accomplished through a collaborative project between US and French research groups, who will...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $769,831 to the Regents of the University of Minnesota to study the mechanism of DNA packaging for double-stranded DNA viruses. The research will focus on the Bacillus subtilis bacteriophage F29, using an integrated genetic, biochemical, single-molecule, and structural approach to characterize protein...
This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
This $659,949 Project Grant award from the National Institute of General Medical Sciences (NIGMS), funded under CFDA 93.859 Biomedical Research and Research Training program, supports research at the University of Connecticut to investigate the assembly and host interactions of bacteriophage P22, a model double-stranded DNA virus. The key goals are to 1) reveal how the phage scaffolding protein interacts with capsid proteins to control proper assembly, 2) understand the scaffolding protein...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $653,693 to Emory University to conduct structural studies of the HIV-1 virus. The research aims to gain a detailed understanding of the molecular mechanisms underlying HIV-1 assembly, maturation, and entry into host cells. The work will leverage advanced cryo-electron microscopy and tomography techniques to...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
This federal Project Grant award from the National Institutes of Health (NIH), under the Trans-NIH Research Support (CFDA 93.310) program, provides $1,367,863 to Emory University to conduct biophysical research on herpesvirus capsid assembly and genome packaging. The goal is to develop new methodologies to monitor these essential viral processes in real-time, which could lead to a more complete understanding of herpesviral replication and the development of improved preventative and...
This $502,043 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a 5-year research program at Brandeis University to investigate the role of transition metals in regulating the activity and function of two key enzyme families: viral proteases and SAMHD1 dNTPases. The research aims to advance the understanding of how metal ions, such as iron and manganese, modulate the catalytic and...
This Project Grant award of $375,430 from the National Institutes of Health's Biomedical Research and Research Training program (CFDA 93.859) supports research to understand how viral pathogens hijack cellular DNA replication and repair machinery for their own benefit. The goal is to develop novel tools and methodologies to interrogate how viruses modulate host genome stability signals, localize to cellular DNA break sites, and tether themselves to these sites for long-term persistence. The...

This $1,736,846 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to gain new insights into the assembly and maturation of deltaretroviruses, a class of complex retroviruses associated with lymphoid leukemias in humans and cattle. The research team at the University of Minnesota will apply advanced imaging techniques such as cryo-electron microscopy, super-resolution microscopy, and dual-color microscopy to investigate the structural features and particle assembly dynamics of deltaretroviruses. This foundational work is expected to provide important knowledge about the mechanisms of enveloped virus assembly at the plasma membrane, which has implications for understanding and potentially disrupting the viral replication cycle. The project period runs from July 15, 2024 to May 31, 2028.

Generated 7/1/25, 4:33 AM