This Project Grant award, totaling $248,999.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The project aims to investigate the role of mitochondrial-endoplasmic reticulum (ER) contact sites, known as mitochondria/ER contacts (MERCs), in regulating the release of mitochondrial DNA (mtDNA) and coordinating innate immune responses to viral infections. Specifically, the research will examine whether MERCs stimulate mtDNA release during infections by DNA viruses like herpes simplex virus-1 (HSV-1) and Epstein-Barr virus (EBV), and whether this benefits the host cell or the virus. The project will also test whether the mitochondrial protein MFN1 enhances innate immune responses to cytoplasmic DNA and RNA by interacting with the DNA sensor STING and the RNA sensor MAVS at MERCs. Additionally, the research will explore whether RNA viruses like influenza A and SARS-CoV-2 disrupt MERCs, leading to mtDNA release and improved antiviral defenses. This award, with an expected completion date of May 31, 2027, will support the primary investigator's transition to an independent research career focused on the role of mitochondria in innate immunity.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $249.0k | 7/4/24 |