This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research on how Herpes Simplex Virus (HSV) manipulates the DNA damage response and cellular proteome to promote viral infection and replication. The $651,832 award to The Children's Hospital of Philadelphia (CHOP) Research Institute will fund a 5-year research project to define the interplay between viral-induced...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,273 to the University of Massachusetts Medical School (UMass Medical) to identify the mechanisms by which Herpes Simplex Virus 1 (HSV-1) activates and inhibits the NLRP1 inflammasome pathway, and to understand the role of NLRP1 in antiviral defense in human skin. The 5-year project, awarded on November 12, 2024,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $881,878 to the Fred Hutchinson Cancer Center in Seattle, WA to conduct research on the interactions between keratinocytes and skin-resident T-cells and their influence on herpes simplex virus (HSV) recurrence. The research aims to dissect the cross-talk between tissue-resident memory T-cells (TRM) and the surrounding skin epithelium,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $215,810 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the mechanisms by which the Herpes Simplex Virus Type 1 (HSV-1) degrades host proteins in neurons to enable viral replication and reactivation. The key objectives of the project are to: 1) Identify the host proteins degraded in neurons...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $236,292 to Tufts University School of Medicine to characterize the structures of key herpes simplex virus (HSV) glycoprotein complexes involved in viral cell entry. The research aims to use novel methods to isolate and stabilize the GD/GH/GL and GH/GL/GB glycoprotein complexes, and then determine their...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to study the role of the Pellino1 (PELI1) protein in regulating antiviral immunity in the skin epidermis. The $384,363 award to Temple University will support research to understand how PELI1 functions to limit the spread of the herpes simplex virus (HSV-1) in the skin, with the goal of identifying potential new...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a potentially curative gene editing therapy for latent Herpes Simplex Virus type 2 (HSV-2) infection. The $303,731 grant to Caladan Therapeutics, Inc. supports research to select an optimized meganuclease variant that can effectively target and eliminate latent HSV-2 DNA in ganglionic neurons, which is the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $811,892 to the University of Kansas Center for Research Inc. to investigate the role of the herpes simplex virus (HSV) protein ICP0 in viral pathogenesis. The key objectives are to: 1) identify the specific ICP0-ICP0 dimerization contacts that stimulate HSV gene expression, and 2) determine how ICP0 dimerization...
This $1,486,800 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Albert Einstein College of Medicine into antibody-dependent cell-mediated cytotoxicity (ADCC) for vaccine development against herpes simplex virus (HSV). The project aims to investigate the role of TNFRSF14 signaling in promoting ADCC responses and develop new strategies for future vaccine and...
This federal Project Grant award from the National Institutes of Health (NIH), under the Trans-NIH Research Support (CFDA 93.310) program, provides $1,367,863 to Emory University to conduct biophysical research on herpesvirus capsid assembly and genome packaging. The goal is to develop new methodologies to monitor these essential viral processes in real-time, which could lead to a more complete understanding of herpesviral replication and the development of improved preventative and...