This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
This Project Grant award for $250,000 was provided by the National Science Foundation (NSF) under the Social, Behavioral, and Economic Sciences (CFDA 47.075) program. The award will support research at the University of Alabama to develop new biomanufacturing methods for producing and characterizing extracellular vesicles (EVs) - small cellular particles that may have applications in drug delivery and regenerative medicine. The project aims to address key challenges in scalable EV production and...
The Project Grant award R56ES034423 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $445,500 to the University of Alabama at Birmingham (UAB) to study the role of extracellular vesicles (EVs) and exosomes as mediators of injury from inhaled exposures to toxic chemicals such as sulfur mustard and chlorine. The project aims to: (A) characterize EVs/exosomes derived from the bronchoalveolar lavage fluid...
This National Science Foundation (NSF) Project Grant under CFDA Number 47.041 - Engineering provides $360,000 in funding to Cornell University from July 1, 2023 to June 30, 2026 to develop a novel biosensing platform for the simultaneous detection and quantification of exosomes (small vesicles released from cells) and their molecular cargo. The key objectives are to: (1) develop methods to capture, quantify, and profile exosomes using a plasmonic biosensor; (2) develop techniques to lyse the...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research focused on understanding the biogenesis, uptake, and cellular response to ribonucleoprotein (RNP) cargoes within extracellular vesicles (EVs). The $300,000 award to Vanderbilt University, effective March 1, 2024, will fund work to characterize the assembly of EV-associated RNP complexes and how they are delivered and act within recipient cells. The project utilizes the EV-CLASP...
This federal Project Grant award for $576,716.86 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports research and development of advanced technologies for characterizing extracellular vesicles (EVs) to improve ovarian cancer detection and monitoring. The award to Northwestern University aims to combine machine learning-enabled inverse design...
This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
This $882,000 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports research to engineer hybrid extracellular vesicles (HEVs) derived from natural killer (NK) cells for targeted cancer imaging and therapy. The University of Texas at Tyler, the awardee, will develop HEVs containing anticancer drugs and imaging agents, and...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,386,000 to the University of Utah to develop an innovative "Extracellular Vesicle Tricorder" technology. This technology aims to enable population-level monitoring of the human exposome and its impact on health by analyzing proteins, DNA, RNA, and other analytes in circulating extracellular vesicles obtained from blood samples. The project will integrate three key technologies - VET-Seq for single-vesicle analysis, OrganView for organ-specific biological insights, and a Vesicle Processing Unit for large-scale EV measurements. This 3-year project, starting in September 2024, will focus on investigating the environmental impact on human lungs as a proof-of-concept. The deliverables include developing the analytical infrastructure, validating the technology, and applying it to enable population-level exposomic surveillance, with the goal of deepening our understanding of the human exposome and uncovering unknown environmental health threats.