Project Grant 2427919

Award Date 6/1/25
Completion Date 5/31/27
Dollars Obligated $250K
Funding Federal Agency
Division of Materials Research
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Tuscaloosa, AL 35401, USA
Similar Awards
This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
The National Science Foundation awarded the University of Virginia a $133,333 project grant under the Engineering federal grant program (CFDA 47.041). The grant will fund a collaborative research project investigating the role of microenvironments, manufacturing processes, and metabolism on mesenchymal stromal cell production of extracellular vesicles. Specifically, the University will examine the effects of three-dimensional hydrogel microenvironments and manufacturing strategies on...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research focused on understanding the biogenesis, uptake, and cellular response to ribonucleoprotein (RNP) cargoes within extracellular vesicles (EVs). The $300,000 award to Vanderbilt University, effective March 1, 2024, will fund work to characterize the assembly of EV-associated RNP complexes and how they are delivered and act within recipient cells. The project utilizes the EV-CLASP...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
This $304,951 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of fibroblast-derived engineered extracellular vesicles (EVs) as a new nucleic acid therapeutic delivery system for peripheral nervous system (PNS) genetic disorders. The key objectives of this Small Business Technology Transfer (STTR) Phase I project are to optimize methods for EV isolation, purification, and cargo loading...
The National Science Foundation (NSF) Office of Integrative Activities awarded a $738,400 Project Grant to the Morehouse School of Medicine (MSM) to investigate the synergistic effects of engineered extracellular vesicles (EVs) from stem cells and macrophages on angiogenesis, the formation of new blood vessels. The 4-year project will explore how EVs from different cell types cooperatively regulate normal and pathological angiogenesis, as well as develop novel EV-based therapeutic strategies....
This $503,611 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program supports research to create enzyme-containing vesicles with stimuli-responsive partitioning behavior. The goal is to improve the reactivity and simultaneous product separation of enzymatic chemical reactions, particularly for the dehalogenase enzyme. Key activities include: (1) developing and characterizing pH-sensitive enzyme vesicles, (2) assessing partitioning of enzyme...
The University of Georgia Research Foundation, Inc. received a $200,000 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The three-year award runs from June 2023 to May 2026 to investigate the role of microenvironment, manufacturing processes, and metabolism on mesenchymal stromal cell production of extracellular vesicles. Specifically, the University of Georgia Research...

This $249,950 Project Grant award from the National Science Foundation's (NSF) Division of Materials Research (DMR) and Office of Multidisciplinary Activities (SBE/SMA) aims to develop new biomanufacturing methods for the scalable production and consistent characterization of extracellular vesicles (EVs). EVs are small particles released by cells that may have applications in drug delivery and disease treatment, but current manufacturing processes result in variable EV size and composition, making consistent dosing difficult.

The project will integrate flow filtration and size focusing techniques to enable large-scale, standardized EV production. It will utilize multiple analysis methods to establish links between EV characteristics like concentration and protein content, enabling more precise and reliable dosing strategies. The effectiveness of the optimized EVs will be evaluated using drug-resistant breast cancer cells as model systems. Beyond scientific advancements, the project will support STEM education and workforce development through student training, course development, and outreach to pre-college students. The award term runs from June 1, 2025 to May 31, 2027.

Generated 7/1/25, 4:15 AM