The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, received a $545,682 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health) to develop a molecular toolbox for non-invasive, spatiotemporally controlled induction of specific cell death pathways in living animals. The objectives are to engineer temperature-responsive protein constructs that can trigger apoptosis, necroptosis, or pyroptosis upon either cooling or gentle heating, and to validate their efficacy in mouse cancer models. Successful development of this technology would open new avenues for fundamental discovery and therapeutic translation by enabling remote control of diverse cellular and molecular events within living mammals.
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