Project Grant DP2CA311217
Award Date 9/1/25
Completion Date 8/31/28
Dollars Obligated $1.4M
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
- The National Institutes of Health (NIH) awarded a $384,999 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University (Stanford University) to develop "smart" gene therapies that utilize injury-specific regulatory elements to enable dynamic, real-time adaptation of therapeutic gene expression to disease conditions. The key objectives are to: 1) Harness endoplasmic reticulum (ER) stress-responsive promoters to achieve...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $1,400,954.00 to The Leland Stanford Junior University to conduct research on combinatorial engineering of multicellular synthetic immunotherapy systems. The research program aims to: (1) co-optimize chimeric antigen receptors (CARs) and synthetic cytokine receptors (SCRs) to enhance anti-tumor immune cell function; (2) co-engineer T cells,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,117,247.00 to The Leland Stanford Junior University (Stanford University) to support research on the genetic basis of complex traits from yeast to humans. The research aims to uncover the evolutionary origins of complex polygenic traits, which underlie most human diseases, by leveraging high-throughput precision genome...
- This Project Grant award from the Trans-NIH Research Support program, CFDA #93.310, provides $1,350,770 to The Leland Stanford Junior University to develop a novel class of synthetic RNA-based receptors to enhance the targeting precision of mRNA-mediated adoptive cell therapies. The project aims to create a modular, programmable receptor system that can convert ligand-induced dimerization events into the expression of desired output proteins, enabling improved specificity for ablating target...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $385,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). This 2-year grant, effective February 1, 2025, will support the development of an inducible and multiplexed dual gene modulation CRISPR system to study neuronal activity and regeneration. The goal is to create a synthetic biology...
- This federal Project Grant award of $462,119, granted on September 8, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project led by The Leland Stanford Junior University (Stanford University) to develop a new live-cell imaging technology called "Transposon Accelerated Chromatin Kinetic Imaging Technology" (TRACK-IT). This technology aims to enable...
- The Project Grant award, valued at $384,999 and provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports a research project conducted by The Leland Stanford Junior University (Stanford University). The project aims to address significant challenges in understanding RNA structure and its critical biological roles through a three-pronged approach: Developing computational tools, including an RNA sequence database (RNAMASS) and a novel...
- This $438,900 Project Grant was awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant funds research to develop a "three-cell (T-NK-macrophage) immunotherapy system" using chimeric antigen receptor (CAR) and synthetic cytokine receptor (SCR) technologies. The primary goal is to engineer the three immune cell types to function...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to improve the efficiency of CRISPR gene editing in human pluripotent stem cells. The goal is to develop a novel carbon nanotube array technology that can efficiently transfer nucleic acids and proteins into these cells to enhance CRISPR-based gene editing and homology-directed recombination. The $275,045 award to Advanced Gene...
- This federal Project Grant award of $200,000, made by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041), aims to integrate non-viral CRISPR gene activation and deep learning to understand the impact of cell manipulation and gene activation on stem cell differentiation. The key objectives are to: (1) decouple the effects of cell transfection and CRISPR-mediated activation (CRISPRa) on mesenchymal stromal cell (MSC) therapeutic capacity, and (2) bridge the gap...