Project Grant DP5OD039444
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $385,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). This 2-year grant, effective February 1, 2025, will support the development of an inducible and multiplexed dual gene modulation CRISPR system to study neuronal activity and regeneration. The goal is to create a synthetic biology...
- The National Institutes of Health (NIH) awarded a $1,413,277 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University (Stanford University) to develop and apply two key technical innovations: 1) CRISPR-ALL, an arbitrarily combinatorial genetic perturbation platform in primary human cells, and 2) the combinatorial construction of new "non-evolved" human genes from existing functional human protein domains, initially focusing on...
- This Project Grant award of $619,681 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to develop innovative tools and techniques for studying the complex genetic interactions underlying the development of Alzheimer's disease (AD). The award, with a period of performance from March 2025 to January 2030, will enable the Leland Stanford Junior University to create "Combo-Seq/Tag", a toolkit that combines gene editing to install multiple AD risk...
- This Project Grant award from the Trans-NIH Research Support program, CFDA #93.310, provides $1,350,770 to The Leland Stanford Junior University to develop a novel class of synthetic RNA-based receptors to enhance the targeting precision of mRNA-mediated adoptive cell therapies. The project aims to create a modular, programmable receptor system that can convert ligand-induced dimerization events into the expression of desired output proteins, enabling improved specificity for ablating target...
- The Project Grant award, valued at $384,999 and provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports a research project conducted by The Leland Stanford Junior University (Stanford University). The project aims to address significant challenges in understanding RNA structure and its critical biological roles through a three-pronged approach: Developing computational tools, including an RNA sequence database (RNAMASS) and a novel...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,117,247.00 to The Leland Stanford Junior University (Stanford University) to support research on the genetic basis of complex traits from yeast to humans. The research aims to uncover the evolutionary origins of complex polygenic traits, which underlie most human diseases, by leveraging high-throughput precision genome...
- This federal Project Grant award of $462,119, granted on September 8, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project led by The Leland Stanford Junior University (Stanford University) to develop a new live-cell imaging technology called "Transposon Accelerated Chromatin Kinetic Imaging Technology" (TRACK-IT). This technology aims to enable...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, consolidates multiple research projects into a single larger R35 grant to enable comprehensive exploration of biological mechanisms underlying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's disease. The...
- This Project Grant award of $762,636 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by The Leland Stanford Junior University to develop interpretable machine learning (ML) methods for analyzing the genetics of Alzheimer's disease (AD). The objective is to discover causal genetic variants that could lead to new AD therapies. The work involves pairing rigorous feature selection in ML with causal inference to identify genetic variants that influence AD risk,...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $1,400,954.00 to The Leland Stanford Junior University to conduct research on combinatorial engineering of multicellular synthetic immunotherapy systems. The research program aims to: (1) co-optimize chimeric antigen receptors (CARs) and synthetic cytokine receptors (SCRs) to enhance anti-tumor immune cell function; (2) co-engineer T cells,...
The National Institutes of Health (NIH) awarded a $384,999 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University (Stanford University) to develop "smart" gene therapies that utilize injury-specific regulatory elements to enable dynamic, real-time adaptation of therapeutic gene expression to disease conditions. The key objectives are to: 1) Harness endoplasmic reticulum (ER) stress-responsive promoters to achieve injury-inducible gene expression and neuroprotection, and optimize these promoters for precise gene regulation, and 2) Develop a CRISPR multiplexing platform using a dual-AAV system to deliver a hyper-efficient Cas12a variant for activation of endogenous neuroprotective pathways and multiplexed CRISPR inhibition. The award period is from Aug 12, 2025 to Jul 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $385.0k | 8/12/25 |